{"product_id":"biolegend-644301","title":"Biolegend, 644301, Purified anti-Syk Antibody, 25μg","description":"\u003cp\u003eSyk is a cytoplasmic 72 kD non-receptor tyrosine kinase that is widely expressed in hematopoietic cells. The Syk kinase associates with a number of proteins including c-Src, Lck, Lyn, Fyn, Vav1, STAT3, SHP1, Grb2, and LAT to couple immunoreceptors to downstream signaling events mediating cellular proliferation, differentiation, and phagocytosis. Syk is modified by phosphorylation on multiple tyrosine sites\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human Syk peptide aa314-339\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested IHC-P - Verified IP, ICFC - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 0.5-1 µg per ml antibody dilution buffer. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 10.0 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This product is for in vitro research use only. It is not to be used for commercial purposes. Use of this product to produce products for sale or for diagnostic therapeutic or drug discovery purposes is prohibited. In order to obtain a license to use this product for commercial purposes, contact The Regents of the University of California.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Van Oers, et al. 1995. J. Exp. Med. 182:1585 Chu DH, et al. 1999. J. Immunol. 163:2610.\u003cbr\u003e\nProduct Citations: Chen L, et al. 2024. JCI Insight. :9. PubMed Bauer B, et al. 2017. J Biol Chem. 292(8):3213-3223. PubMed Foster G, et al. 2015. J Immunol. 195: 5380 - 5392. PubMed\u003cbr\u003e\nRRID: AB_2200267 (BioLegend Cat. No. 644301) AB_2287062 (BioLegend Cat. No. 644302)\u003cbr\u003e\nStructure: Non-receptor associated tyrosine kinase, contains 2 SH2 domains, 72 kD\u003cbr\u003e\nDistribution: Cytoplasmic protein, widely expressed in hematopoietic cells\u003cbr\u003e\nFunction: Couples immunoreceptor to downstream signaling events that mediate cellular responses including proliferation, differentiation, and phagocytosis\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Signal Transduction\u003cbr\u003e\nAntigen References: 1. Taniguchi T, et al. 1991. J. Biol. Chem. 266:15790. 2. Toyabe SL, et al. 2001.Immunology 103:164.\u003cbr\u003e\nGene ID: 6850\u003cbr\u003e\nUniProt: View information about Syk on UniProt.org\u003cbr\u003e\nClone: 4D10.2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Spleen tyrosine kinase, protein tyrosine kinase SYK\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862413988009,"sku":"644301","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-644301","provider":"Iright","version":"1.0","type":"link"}