{"product_id":"biolegend-648811","title":"Biolegend, 648811, Purified anti-human CD279 (PD-1) Antibody, 100μg","description":"\u003cp\u003eProgrammed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PDL2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Human PD-1 Recombinant Protein (His \u0026amp; Fc Tag)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: Direct ELISA - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Direct ELISA. The optimal concentration of this reagent for the specific application and the experiment design should be established by the end-user.\u003cbr\u003e\nAdditional Product Notes: This product is intended for sandwich-based immunoassay development on various assay platforms requiring antibody pairs. This antibody (clone A20074H) could function as a capture antibody when paired with biotin anti-human PD-1 antibody (Cat. No. 621627) (clone A17188B) as the detection antibody and using Recombinant Human PD-1 (carrier-free) protein as the assay standard.\u003cbr\u003e\nRRID: AB_3717175 (BioLegend Cat. No. 648811)\u003cbr\u003e\nStructure: Immunoglobulin superfamily\u003cbr\u003e\nDistribution: Transiently expressed on CD4- CD8- thymocytes; upregulated in thymocytes and splenic T and B lymphocytes; expressed on activated myeloid cells\u003cbr\u003e\nFunction: Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self\u003cbr\u003e\nInteraction: APC, monocytes, dendritic cells, stromal cell, cancer cells\u003cbr\u003e\nLigand\/Receptor: B7-H1 (also known as PD-L1) and B7-DC (PD-L2)\u003cbr\u003e\nCell Type: Lymphocytes, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immuno-Oncology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Ishida Y, et al. 1992. EMBO J. 11:3887. Fife BT, et al. 2009. Nature Immunol. 10:1185-92. Freeman GJ, et al. 2000. J Exp Med. 192:1027. Latchman Y, et al. 2001. Nat Immunol. 2001 2:261. Iwai Y, et al. 2002. Proc Natl Acad Sci USA. 99:12293-7. Dai S, et al. 2014. Cell Immunol. 290:72. Tan S, et al. 2017. Nature Commun. 8:14369.\u003cbr\u003e\nGene ID: 5133\u003cbr\u003e\nUniProt: View information about CD279 on UniProt.org\u003cbr\u003e\nClone: A20074H\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Programmed cell death protein 1, Protein PD-1, hPD-1, CD279\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866069848233,"sku":"648811","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-648811","provider":"Iright","version":"1.0","type":"link"}