{"product_id":"biolegend-648832","title":"Biolegend, 648832, Purified anti-VILIP-1 Antibody, 25μg","description":"\u003cp\u003eVisinin-like protein 1 (VILIP-1) is a member of the neuronal calcium sensor (NCS) protein family and plays an essential role in calcium-mediated signal transduction within the human central nervous system. VILIP-1 contains EF-hand motifs that bind calcium ions, leading to conformational changes that allow it to interact with various target proteins such as adenylyl cyclases and membrane-associated signaling molecules. Through these interactions, VILIP-1 modulates cyclic nucleotide signaling and synaptic plasticity, processes fundamental to learning, memory, and neuronal development.  In Alzheimer’s disease (AD), neuronal injury and synaptic dysfunction result in the release of VILIP-1 into the cerebrospinal fluid (CSF), where it can be detected at elevated levels. CSF VILIP-1 levels correlate with biomarkers of neuronal degeneration such as total Tau and phosphorylated Tau, and can predict cognitive decline and progression from mild cognitive impairment (MCI) to AD.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human VILIP-1 recombinant protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested IHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg\/mL. For immunocytochemistry, a concentration range of 1.0 - 10.0 μg\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nAdditional Product Notes: For use in immunohistochemistry on formalin-fixed paraffin-embedded tissue (IHC-P), it is recommended to perform antigen retrieval using either Citrate Buffer, 10X (Cat. No. 420902) or Tris-EDTA pH 9.0 Antigen Retrieval Buffer (10X) (Cat. No. 422704).\u003cbr\u003e\nRRID: AB_3717216 (BioLegend Cat. No. 648832) AB_3717216 (BioLegend Cat. No. 648833)\u003cbr\u003e\nStructure: VILIP-1 is a 191 amino acid length protein with a predicted molecular weight of 22.1 kD.\u003cbr\u003e\nDistribution: Cytoplasm\u003cbr\u003e\nCell Type: Neurons\u003cbr\u003e\nBiology Area: Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Signal Transduction\u003cbr\u003e\nAntigen References: Bernstein HG, et al. 1999. J. Neurocytol. 28:655-62. Tarawneh R, et al. 2012. Neurology. 78:709-19. Dulewicz M, et al. 2020. Int. J. Mol. Sci. 21:8335.\u003cbr\u003e\nGene ID: 7447\u003cbr\u003e\nUniProt: View information about VILIP-1 on UniProt.org\u003cbr\u003e\nClone: A22106J\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Visinin-like protein 1, VILIP, VILIP1, VLP-1, VLP1, VSNL1, VISL1, Hippocalcin-like protein 3 , HLP3\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866077384873,"sku":"648832","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-648832","provider":"Iright","version":"1.0","type":"link"}