{"product_id":"biolegend-648873","title":"Biolegend, 648873, Purified anti-FABP2 Antibody, 100μg","description":"\u003cp\u003eFatty acid-binding protein 2 (FABP2), also known as intestinal fatty acid-binding protein (I-FABP), is a small intracellular lipid-binding protein primarily expressed in the enterocytes of the small intestine. FABP2 belongs to the family of fatty acid-binding proteins that play crucial roles in lipid metabolism by binding long-chain fatty acids and other hydrophobic ligands. FABP2 is involved in the uptake, transport, and intracellular trafficking of dietary fatty acids from the intestinal lumen to metabolic or storage pathways, acting as a lipid chaperone. It contributes significantly to the regulation of lipid absorption and energy homeostasis. A polymorphism in FABP2, Ala54Thr (rs1799883), results in an amino acid substitution at position 54 and has been extensively studied for its metabolic implications. This variant is linked to several metabolic disorders, including insulin resistance, type 2 diabetes mellitus (T2DM), dyslipidemia, and obesity. In cardiovascular disease, FABP2 variants and expression levels are associated with altered lipid profiles and atherogenic risk, likely due to disrupted lipid transport from the gut to the circulation.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant fragment of human FABP2\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: IHC-P - Quality tested WB - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 10.0 µg\/mL is suggested. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg\/mL. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nAdditional Product Notes: For use in immunohistochemistry on formalin-fixed paraffin-embedded tissue (IHC-P), it is recommended to perform antigen retrieval using either Citrate Buffer, 10X (Cat. No. 420902) or Tris-EDTA pH 9.0 Antigen Retrieval Buffer (10X) (Cat. No. 422704).\u003cbr\u003e\nRRID: AB_3720601 (BioLegend Cat. No. 648872) AB_3720601 (BioLegend Cat. No. 648873)\u003cbr\u003e\nStructure: FABP2 is a 132 amino acid protein with a predicted molecular weight of 15.2 kD.\u003cbr\u003e\nDistribution: Highly expressed in small intestine, with the highest expression levels in the jejunum. Subcellular localization is in the cytoplasm.\u003cbr\u003e\nBiology Area: Cardiovascular Biology\u003cbr\u003e\nMolecular Family: Apolipoproteins\u003cbr\u003e\nAntigen References: Albala C, et al. 2004. Obes. Res. 12:340-5. Tsai IT, et al. 2020. Int J Med. Sci. 17:2338-2345. Sekimori T, et al. 2024. J Integr Neurosci. 23:44.\u003cbr\u003e\nGene ID: 2169\u003cbr\u003e\nUniProt: View information about FABP2 on UniProt.org\u003cbr\u003e\nClone: W24079A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Fatty acid-binding protein 2, Fatty acid-binding protein, intestinal, FABPI, I-FABP\u003cbr\u003e\nIsotype: Rat IgG2b, λ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864084795561,"sku":"648873","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-648873","provider":"Iright","version":"1.0","type":"link"}