{"product_id":"biolegend-649552","title":"Biolegend, 649552, Purified anti-CD4 Antibody, 100μg","description":"\u003cp\u003eCD4 is a single-chain type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is expressed on most thymocytes, helper T cells, type II NKT cells, and monocytes\/macrophages. CD4 is part of the TCR (T-Cell Receptor)\/CD3 complex and binds to the β2 domain of the MHC class II molecule, and participates in TCR signal transduction. CD4 is the receptor of IL-16 and is a coreceptor for the human immunodeficiency virus (HIV) and human herpes virus 7 (HHV-7).\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant fragment of the extracellular domain of human CD4\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: IHC-P - Quality tested WB - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 10.0 µg\/mL is suggested. For western blotting, the suggested use of this reagent is 0.1 - 1.0 µg\/mL. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: For use in immunohistochemistry on formalin-fixed paraffin-embedded tissue (IHC-P), it is recommended to perform antigen retrieval using Citrate Buffer, 10X (Cat. No. 420902) or Tris-EDTA pH 9.0 Antigen Retrieval Buffer (10X) (Cat. No. 422704). Staining intensity may be stronger using Citrate Buffer. This product is not recommended for use in immunocytochemistry (ICC) or intracellular flow cytometry (ICFC). This product does not react with mouse CD4 in Western Blot (WB) or immunohistochemistry on frozen tissues (IHC-F).\u003cbr\u003e\nRRID: AB_3675180 (BioLegend Cat. No. 649551) AB_3675180 (BioLegend Cat. No. 649552)\u003cbr\u003e\nStructure: CD4 is a 458 amino acid protein with a predicted molecular weight of 51.1 kD.\u003cbr\u003e\nDistribution: Plasma membrane\u003cbr\u003e\nFunction: Co-receptor\u003cbr\u003e\nInteraction: Part of the TCR\/CD3 complex\u003cbr\u003e\nLigand\/Receptor: Β2 domain from MHC class II, IL-16\u003cbr\u003e\nCell Type: Dendritic cells, Macrophages, Monocytes, T cells, Thymocytes, Tregs\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Zhu J, et al. 2010. Annu Rev Immunol. 28:445. Vignali DA. 2010. J. Immunol. 184:5933. Zhou L, et al. 2009. Immunity. 30:646. Singer A, et al. 2008. Nat Rev Immunol. 8:788. Zhu J and Paul WE. 2008. Blood. 112:1557.\u003cbr\u003e\nGene ID: 920\u003cbr\u003e\nUniProt: View information about CD4 on UniProt.org\u003cbr\u003e\nClone: W23082E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T4, Leu3, T-cell surface glycoprotein CD4, T-cell surface antigen T4\/Leu-3\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866437701801,"sku":"649552","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-649552","provider":"Iright","version":"1.0","type":"link"}