{"product_id":"biolegend-654102","title":"Biolegend, 654102, Purified anti-TIF1β (KAP-1, TRIM28) Phospho (Ser473) Antibody, 100μg","description":"\u003cp\u003eTranscriptional intermediary factors (TIFs) are a group of transcriptional coactivators and corepressors that regulate gene expression by modulating chromatin structure and assembly of transcription initiation complexes. TIF1β is a member of the TIF1 subfamily of chromatin-associated TIFs that play a key role in many developmental and physiological processes. Studies using knockout mice reveal the important function of TIF1β in regulating genomic imprinting, T cell activation, and T cell tolerance.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Modified peptide: VKRSRpSGEGEVC.\u003cbr\u003e\nFormulation: This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.Previous lots of this product may have been formulated with 0.1% or 0.05% NaN3 instead of 0.09% NaN3. For further information please contact BioLegend Technical Support or Customer Service.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: Upon receipt, store undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested ICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 1.0 µg per mL. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Jamal K, et al. 2022. Cancer Res Commun. 2:1244. PubMed Boonen RACM, et al. 2022. Cancer Res. 82:615. PubMed Storchova R, et al. 2021. FEBS J. 288:6035. PubMed Zu R, et al. 2021. Cell Death Dis. 12:994. PubMed\u003cbr\u003e\nRRID: AB_2561781 (BioLegend Cat. No. 654101) AB_2561782 (BioLegend Cat. No. 654102)\u003cbr\u003e\nStructure: An N-terminal RING-B box coiled coil (RBCC) domain most likely attributes to intermolecular structure, while two characteristic chromatin-targeting domains, a plextrin homology (PH) finger motif and bromodomain, are found in the C-terminus.\u003cbr\u003e\nDistribution: Nucleus\u003cbr\u003e\nFunction: TIF1β acts as a transcriptional repressor by modulating histone deacetlyation, histone H3 Ly-9 methylation, and recruitment of HP1 proteins.\u003cbr\u003e\nInteraction: TIF1β was shown to form homo-oligomers in vitro, but does not form hetero-oligomers with TIF1α or TIF1γ.\u003cbr\u003e\nBiology Area: Cell Biology, Chromatin Remodeling\/Epigenetics, Transcription Factors\u003cbr\u003e\nMolecular Family: Phospho-Proteins\u003cbr\u003e\nAntigen References: 1. Messerschmidt DM, et al. 2012. Science 335:1499. 2. Chikuma S, et al. 2012. Nat. Immunol. 13:596.\u003cbr\u003e\nGene ID: 21849\u003cbr\u003e\nUniProt: View information about TIF1beta on UniProt.org\u003cbr\u003e\nClone: 11G10SC\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: TRIM28 pS473, KAP-1 pS473\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860793839785,"sku":"654102","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-654102","provider":"Iright","version":"1.0","type":"link"}