{"product_id":"biolegend-655552","title":"Biolegend, 655552, Purified anti-ITPR1 Antibody, 100μg","description":"\u003cp\u003eITPR1 is primarily involved in calcium signaling within cells. Located on the membrane of the endoplasmic reticulum (ER), it functions as a calcium channel. Upon binding to inositol 1,4,5-trisphosphate (IP3), a second messenger molecule, ITPR1 facilitates the release of calcium ions from the ER into the cytoplasm. This calcium release plays a crucial role in regulating various cellular processes, including muscle contraction, neurotransmitter release, and gene expression. Mutations in the ITPR1 gene are associated with neurological disorders such as spinocerebellar ataxia and Gillespie syndrome.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant protein located near the C terminus of human ITPR1\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: IHC-P - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 10.0 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nAdditional Product Notes: For use in immunohistochemistry on formalin-fixed paraffin-embedded tissue (IHC-P), it is recommended to perform antigen retrieval using either Citrate Buffer, 10X (Cat. No. 420902) or Tris-EDTA pH 9.0 Antigen Retrieval Buffer (10X) (Cat. No. 422704). This product (W22192B) is not recommended for use in Western Blot (WB) due to the presence of a non-specific band in addition to the expected band. This product is not recommended for use in intracellular flow cytometry (ICFC) or immunocytochemistry (ICC).\u003cbr\u003e\nRRID: AB_3699081 (BioLegend Cat. No. 655551) AB_3699081 (BioLegend Cat. No. 655552)\u003cbr\u003e\nStructure: ITPR1 is a 2758 amino acid protein with a predicted molecular weight of 313.9 kD.\u003cbr\u003e\nDistribution: Endoplasmic reticulum\u003cbr\u003e\nFunction: IP3-gated calcium channel\u003cbr\u003e\nInteraction: Calmodulin, FKBP1A, Ankyrin-B, HOMER proteins\u003cbr\u003e\nLigand\/Receptor: Inositol 1,4,5-trisphosphate (IP3)\u003cbr\u003e\nBiology Area: Signal Transduction, Synaptic Biology\u003cbr\u003e\nMolecular Family: Endoplasmic Reticulum Markers\u003cbr\u003e\nAntigen References: Tolonen JP, et al. 2024. Mov Disord. 39:141-151. Putney JW, 1987. Am J Physiol. 252:G149-57. van de Leemput J, et al. 2007. PLoS Genet. 3:e108.\u003cbr\u003e\nGene ID: 3708\u003cbr\u003e\nUniProt: View information about ITPR1 on UniProt.org\u003cbr\u003e\nClone: W22192B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Inositol 1,4,5-trisphosphate-gated calcium channel (ITPR1), IP3 receptor isoform 1 (IP3R 1, InsP3R1), Inositol 1,4,5, trisphosphate receptor type 1\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866435276969,"sku":"655552","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-655552","provider":"Iright","version":"1.0","type":"link"}