{"product_id":"biolegend-658802","title":"Biolegend, 658802, Purified anti-XBP-1s Antibody, 100μg","description":"\u003cp\u003eXBP-1 is a transcription factor containing a bZIP domain. It was first identified because of its ability to bind X-box, a conserved transcriptional element in the promoter of the human HLA-DR gene. XBP-1 has multiple functions. It controls MHC class II gene regulation and is also essential for differentiation of plasma cells. XBP-1 is upregulated as part of the ER stress response, also known as the unfolded protein response.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Partial mouse XBP-1s recombinant protein (162-267aa)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested ICC, ChIP - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per mL. For ChIP application, use 2 µg of antibody and 10 µg of chromatin per IP. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: The clone 9D11A43 recognizes spliced XBP-1 (XBP-1s\/isoform 2), which is 371 amino acids and migrates around 55 kD on the SDS-PAGE.\u003cbr\u003e\nAdditional Product Notes: Using this antibody at a ratio higher than 1:5 (µg antibody per ug of chromatin) will increase background\u003cbr\u003e\nProduct Citations: Bezu L, et al. 2018. Cell Death Differ. 25:1375. PubMed Liu Z, et al. 2023. J Neuroinflammation. 20:93. PubMed Sundaram A et al. 2017. eLife. 6 pii: e27187. PubMed Yu W, et al. 2022. Acta Pharm Sin B. 12:2315. PubMed Saito A et al. 2017. Journal of neurochemistry. 144(1):35-49 . PubMed Dion W, et al. 2022. Sci Adv. 8:eabl4150. PubMed Martinez-Turtos A, et al. 2022. Oncoimmunology. 11:2116844. PubMed Sicari D, et al. 2020. FEBS J. 287:27. PubMed\u003cbr\u003e\nRRID: AB_2562960 (BioLegend Cat. No. 658802)\u003cbr\u003e\nDistribution: Nucleus.\u003cbr\u003e\nFunction: Upregulated by ER stress, IL-6, and IL-4. Downregulation correlates with tumor progression in prostate cancer. Downregulated by PAX5 transcription factor.\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Transcription Factors\u003cbr\u003e\nMolecular Family: MHC Antigens, Nuclear Markers\u003cbr\u003e\nAntigen References: 1. Liou HC, et al. 1990. Science 247:1581. 2. Ponath PD, et al. 1993. J. Biol. Chem. 268:17074. 3. Takahashi S, et al. 2002. Prostate 50:154.\u003cbr\u003e\nGene ID: 7494\u003cbr\u003e\nUniProt: View information about XBP-1s on UniProt.org\u003cbr\u003e\nClone: 9D11A43\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: XBP-1 isoform2, Tax-responsive element-binding protein 5 (TREB5), XBP2\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864380461225,"sku":"658802","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-658802","provider":"Iright","version":"1.0","type":"link"}