{"product_id":"biolegend-662102","title":"Biolegend, 662102, Purified anti-C\/EBPα Antibody, 100μg","description":"\u003cp\u003eThe CCAAT-enhancer binding proteins (C\/EBP) are members of the basic region\/leucine zipper (bZIP) transcription factors, that bind to the consensus CCAAT sequence in DNA. C\/EBPα is expressed in two isoforms: p42 and p30 by ultilizing different translational start codons. The C\/EBPα p30 isoform has little to no transactivating activity and acts as an inhibitor. C\/EBPα regulates expression of various myeloid-specific genes and is required for myeloid differentiation. C\/EBPα has been found to play a key role in adipogenesis, since inhibition of C\/EBPα blocks adipocyte differentiation. C\/EBPα also regulates cell cycle progression through interactions with cyclin-dependent kinases (CDK) and by inducing the expression of CDK inhibitor p21. Mutations in the C\/EBPα gene are associated with the development of acute myeloid leukemia.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Synthetic peptide (AKQLALAGLFPYQPPPP) conjugated to KLH.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested ICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 0.5 µg per mL. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This product weakly reacts with Mouse.\u003cbr\u003e\nProduct Citations: Oliveros-Matus P, et al. 2020. Front Pharmacol. 11:303. PubMed Li Y, et al. 2018. Front Immunol. 32:415. PubMed\u003cbr\u003e\nRRID: AB_2564224 (BioLegend Cat. No. 662102)\u003cbr\u003e\nStructure: 358 amino acids with a predicted molecular weight of 38 kD; contains a bZIP domain responsible for DNA binding.\u003cbr\u003e\nDistribution: Nucleus\u003cbr\u003e\nFunction: C\/EBPα is a bZIP transcription factor that regulates proliferation and differentiation of myeloid cells and adipocytes.\u003cbr\u003e\nInteraction: C\/EBPα forms heterodimers with C\/EBPβ and γ; interacts with CDK2, CDK4, PRDM16, UBN1, and ZNF638.\u003cbr\u003e\nCell Type: Neutrophils\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Cell Cycle\/DNA Replication, Immunology, Transcription Factors\u003cbr\u003e\nMolecular Family: Nuclear Markers\u003cbr\u003e\nAntigen References: 1. De Obaldia ME, et al. 2013. Nat. Immunol. 14:1277. 2. Di Tullio A, et al. 2011. Proc. Natl. Acad. Sci. USA. 108:17016. 3. Fan HY, et al. 2011. Mol. Endocrinol. 25:253. 4. Cai DH, et al. 2008. Oncogene. 27:2772. 5. Khanna-Gupta A. 2008. Blood Cells Mol. Dis. 41:77. 6. Janardhan HP. 2008. Sci. Signal. 1:jc2.\u003cbr\u003e\nGene ID: 1050\u003cbr\u003e\nUniProt: View information about C\/EBPalpha on UniProt.org\u003cbr\u003e\nClone: 16C12B70\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CCAAT\/enhancer-binding protein alpha, C\/EBP-A\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864359981225,"sku":"662102","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-662102","provider":"Iright","version":"1.0","type":"link"}