{"product_id":"biolegend-662602","title":"Biolegend, 662602, Purified anti-IL-27\/IL-35 EBI3 (monomer, dimer, heterodimer) Antibody, 100μg","description":"\u003cp\u003eEBI3 is an IL-12 p40-related protein that can heterodimerized with IL-12 p35 to form IL-35, or with an IL-12 p35-related protein, p28, to form IL-27. It is produced by antigen-presenting cells such as B cells, monocytes, and dendritic cells (DCs) following stimulation through TLR. It can regulate T cell differentiation and proliferation. Both IL-27 and IL-35 are anti-inflammatory cytokines that are able to inhibit Th17 generation, promote Th1 differentiation, increase cytolytic activity of CD8 + T cells, and impact B cell differentiation and immunoglobulin production. IL-35 is also involved in tumorigenesis and is a promising biomarker for assessing tumor progression and prognosis in clinical settings.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse EBI3\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2564303 (BioLegend Cat. No. 662602)\u003cbr\u003e\nStructure: 229 amino acids, predicted molecular weight of approximately 25 kD.\u003cbr\u003e\nDistribution: B cells, monocytes, and dendritic cells.\u003cbr\u003e\nFunction: Pro- and anti-inflammatory.\u003cbr\u003e\nInteraction: IL-27 p28 subunit and IL-35 p35 subunit.\u003cbr\u003e\nLigand\/Receptor: WSX-1(TCCR) and gp130.\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Monocytes, Tregs\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Cell Cycle\/DNA Replication, Immunology, Innate Immunity, Signal Transduction\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. Pflanz S, et al. 2002. Immunity 16:779. 2. Takeda A, et al. 2003. J. Immunol. 170:4886. 3. Pflanz S, et al. 2004. J. Immunol. 172:2225. 4. Li MF, et al. 2013. Dev. Comp. Immunol. 41:514. 5. Zeng JC, et al. 2013. Int. J. Clin. Exp. Pathol. 6:1806. 6. Ouyang H, et al. 2014. Am. J. Med. Sci. 348:156.\u003cbr\u003e\nGene ID: 10148\u003cbr\u003e\nUniProt: View information about IL-27 IL-35 on UniProt.org\u003cbr\u003e\nClone: J053B5\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Epstein-Barr Virus Induced 3, EBV-Induced Gene 3 Protein, IL-27 Subunit Beta, IL-27B, IL-35 subunit\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866107105449,"sku":"662602","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-662602","provider":"Iright","version":"1.0","type":"link"}