{"product_id":"biolegend-674802","title":"Biolegend, 674802, Purified anti-Apo E Antibody, 100μg","description":"\u003cp\u003eApo-E is a class of apolipoprotein primarily synthesized in the liver, but is also found in other tissues such as brain, kidneys, and spleen. Apo-E is a protein component of serum chylomicron and lipoprotein particles, playing essential roles in cholesterol transportation, homeostasis, and metabolism. The expression of Apo-E is induced by cholesterol-rich diets and hyperlipoproteinemia. In the central nervous system, Apo-E is produced by astrocytes and microglia. The Apo-E-containing lipoprotein particles play important functions in brain injury repair, neurogenesis, and synaptic plasticity. Apo-E has been found to be involved in the regulation of amyloid-β aggregation and clearance. Genetic polymorphisms of Apo-E are associated with neuron degenerative disorders including Alzheimer's disease.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Full length mouse Apo-E recombinant protein expressed in E. coli.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Moon HJ, et al. 2022. Neurobiol Dis. 164:105631. PubMed Jeong A, et al. 2021. Acta Neuropathol Commun. 9:129. PubMed\u003cbr\u003e\nRRID: AB_2565426 (BioLegend Cat. No. 674802)\u003cbr\u003e\nStructure: 293 amino acids, predicted molecular weight of 34 kD (mature form), and contains one LDL receptor binding domain and two heparin binding regions.\u003cbr\u003e\nFunction: Apo-E is a component of serum chylomicron, VLDL, and HDL particles, and mediates lipid metabolism and memory formation.\u003cbr\u003e\nInteraction: SET, KCNMA1, SAA, and PRNP.\u003cbr\u003e\nBiology Area: Cell Biology, Neurodegeneration, Neuroscience, Protein Trafficking and Clearance\u003cbr\u003e\nAntigen References: 1. Hayes EM, et al. 2014. Front Immunol. 5:537. 2. Kim J, et al. 2014. Mol. Cells 37:767. 3. Verghese PB, et al. 2013. Proc. Natl. Acad. Sci. USA 110:E1807. 4. Mahley RW, et al. 2012. Neuron 76:871. 5. Holtzman DM, et al. 2012. Cold Spring Harb. Perspect. Med. 2:a006312. 6. Zhang HL, et al. 2010. Clin. Dev. Immunol. 2010:186813.\u003cbr\u003e\nGene ID: 11816\u003cbr\u003e\nUniProt: View information about Apo E on UniProt.org\u003cbr\u003e\nClone: 3B3C32\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Apolipoprotein E, ApoE\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864371581097,"sku":"674802","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-674802","provider":"Iright","version":"1.0","type":"link"}