{"product_id":"biolegend-678202","title":"Biolegend, 678202, Purified anti-CXCL12 (SDF-1β) Antibody, 100μg","description":"\u003cp\u003eSDF-1, also known as CXCL12, has different variants, which include SDF-1α, SDF-1β, and SDF-1γ derived from alternative splicing. SDF-1 is highly expressed in bone marrow stromal stem cells and regulates growth and survival. CXCL12 promotes survival by inducing anti-apoptotic proteins, decreasing apoptotic proteins, and increasing transcription of cell survival genes. The SDF-1\/CXCR4 pair plays a key role in maintaining proliferation and survival of bone marrow stem cell subpopulations under stress conditions. Data suggests that SDF-1β mediates cells' survival by enhancing autophagy in bone marrow mesenchymal stem cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant mouse SDF-1β\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2565915 (BioLegend Cat. No. 678202)\u003cbr\u003e\nStructure: 72 amino acids with a predicted molecular weight approximately at 8.5 kD.\u003cbr\u003e\nDistribution: Expressed by bone marrow stromal cells, endothelial cells, epithelial cells, pericytes, dendritic cells, and fibroblasts.\u003cbr\u003e\nFunction: SDF-1 is a constitutively produced chemokine involved in lung, brain, joint, and intestine inflammation. SDF-1 is chemotactic for T, B, and cancer sells. SDF-1\/CXCR4 pair plays a role in the mobilization of CD34+ progenitors to peripheral blood. SDF-1 is important in morphogenesis, angiogenesis, and cancer metastasis.\u003cbr\u003e\nInteraction: CXCR4 and ACKR3.\u003cbr\u003e\nLigand\/Receptor: CXCR4.\u003cbr\u003e\nCell Type: Dendritic cells, Endothelial cells, Epithelial cells, Fibroblasts\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Immunology, Signal Transduction, Transcription Factors\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. Nagasawa T, et al. 1994. Proc. Natl. Acad. Sci. USA 91:2305. 2. Muller A, et al. 2001. Nature 410:50. 3. Valenzuela-Fernandez A, et al. 2002. J. Biol. Chem. 277:15677. 4. De La Luz Sierra M, et al. 2004. Blood 103:2452. 5. Kortesidis A, et al. 2005. Blood 105:3793. 6. Davis DA, et al. 2005. Blood 105:4561. 7. Zlotnik A. 2008. J. Pathol. 215:211. 8. Herberg S, et al. 2013. PLoS One 8:e58207.\u003cbr\u003e\nGene ID: 20315\u003cbr\u003e\nUniProt: View information about CXCL12 on UniProt.org\u003cbr\u003e\nClone: M4201G03\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Pre-B-cell growth-stimulating factor (PBSF), stromal cell derived factor 1 isoform beta precursor (SDF-1β), TLSF, TPAR1, SCYB12, IRH\u003cbr\u003e\nIsotype: Rat IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866124079273,"sku":"678202","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-678202","provider":"Iright","version":"1.0","type":"link"}