{"product_id":"biolegend-682604","title":"Biolegend, 682604, Alexa Fluor® 594 anti-TOX Antibody, 100μg","description":"\u003cp\u003eTOX is a member of the high-mobility group (HMG) box superfamily of DNA-binding proteins and is originally identified as the thymic transcript expressed in CD4 + CD8 + double positive T-cells. TOX is also defined as part of a small subfamily of transcription factors consisting of TOX2, TOX3, and TOX4, which share conserved HMG-box sequences. TOX is highly upregulated in thymocytes undergoing positive selection and is required for the differentiation and development of various T-cell subsets, such as CD4 + T cells, regulatory T cells, and natural killer T cells (NKTs). TOX-deficient mice fail to develop lymph nodes and have significantly diminished numbers of CD4+ T-cells, NK cells, and ILC cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human TOX recombinant protein (66-301 a.a.) expressed in E. coli.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunocytochemistry. For immunocytochemistry, a concentration range of 1.0 - 5.0 μg\/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nApplication Notes: The immunogen used to generate clone 6E6D03 is the N-terminus of Tox1, which is highly conserved among Tox family member proteins. Hence, this clone may recognize multiple Tox family members. Predicted MW for Tox family members: Tox 1 is 57.5 kD, Tox 2 is 49, 52, 53, 55 kD, Tox 3 is 63 kD and Tox 4 is 64, 66 kD.\u003cbr\u003e\nRRID: AB_2566786 (BioLegend Cat. No. 682604)\u003cbr\u003e\nStructure: 562 amino acids with a predicted molecular weight of 57.5 kD. Contains a high mobility group (HMG) box domain responsible for DNA binding.\u003cbr\u003e\nDistribution: Nucleus.\u003cbr\u003e\nFunction: TOX is a transcription factor required for development of various T lymphocyte subsets.\u003cbr\u003e\nInteraction: TOX interacts with ZDHHC17.\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Transcription Factors\u003cbr\u003e\nMolecular Family: Nuclear Markers\u003cbr\u003e\nAntigen References: 1. Spits H. 2015. Nat. Immunol. 16:594. 2. Seehus CR, et al. 2015. Nat. Immunol. 16:599. 3. Huang Y, et al. 2015. Blood 125:1435. 4. Aliahmad P, et al. 2012. Curr. Opin. Immunol. 24:173. 6. Di Santo JP. 2010. Nat. Immunol. 11:885. 7. Aliahmad P, et al. 2004. J. Exp. Med. 199:1089.\u003cbr\u003e\nGene ID: 9760\u003cbr\u003e\nUniProt: View information about TOX on UniProt.org\u003cbr\u003e\nClone: 6E6D03\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Thymocyte Selection-Associated High Mobility Group Box, Thymus High Mobility Group Box Protein TOX, TOX1, KIAA0808\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864376955049,"sku":"682604","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-682604","provider":"Iright","version":"1.0","type":"link"}