{"product_id":"biolegend-686302","title":"Biolegend, 686302, Purified anti-FOXO3 Antibody, 100μg","description":"\u003cp\u003eThe Fork-head box O (FOXO) family of transcription factors is comprised of four family members; FOXO1, FOXO3, FOXO4, and FOXO6. FOXO3 was originally identified as a tumor suppressor and has been shown to regulate several cellular processes, such as cell cycle arrest, apoptosis, autophagy, longevity, and stress response. FOXO3 activity is determined by its post-translational modifications and subcellular localization. FOXO3 is inactivated by cytoplasmic retension through AKT\/PI3K signaling pathways. FOXO3 inactivation has been associated with cell proliferation and tumorigenesis. In contrast, over-expression of FOXO3 leads to inhibition of tumor growth. FOXO3 also plays an important role in the development of regulatory T cells. FOXO3-deficient mice showed organ inflammation phenotype and increased production of proinflammatory cytokines during viral infection.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human FOXO3 recombinant protein (424-673 a.a.) expressed in E. coli.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested KO\/KD-WB - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2616882 (BioLegend Cat. No. 686302)\u003cbr\u003e\nStructure: 673 amino acids with a predicted molecular weight of 71.3 kD. Contains a fork-head domain responsible for DNA binding.\u003cbr\u003e\nDistribution: Cytoplasm and nucleus.\u003cbr\u003e\nFunction: FOXO3 is a transcription factor, participating in the regulation of cell cycle arrest, apoptosis, autophagy, longevity, and stress response.\u003cbr\u003e\nInteraction: Interacts with SIRT2, 14-3-3 beta, 14-3-3 zeta, STK4, PIM1, and DDIT3.\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Transcription Factors\u003cbr\u003e\nMolecular Family: Nuclear Markers\u003cbr\u003e\nAntigen References: 1. Morris BJ, et al. 2015. Gerontology 61:515. 2. Larsen SK, et al. 2014. Oncoimmunology 3:e953411. 3. Eijkelenboom A, et al. 2013. Cell Rep. 5:1664. 4. Yeo H, et al. 2013. EMBO J. 32:2589. 5. Pelosi E, et al. 2013. Nat. Commun. 4:1843. 6. Litvak V, et al. 2012. Nature 490:421.\u003cbr\u003e\nGene ID: 2309\u003cbr\u003e\nUniProt: View information about FOXO3 on UniProt.org\u003cbr\u003e\nClone: W15111A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Forkhead box O3, FKHRL1, FOXO3A\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866298962089,"sku":"686302","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-686302","provider":"Iright","version":"1.0","type":"link"}