{"product_id":"biolegend-697802","title":"Biolegend, 697802, Purified anti-Claudin-1 Antibody, 100μg","description":"\u003cp\u003eClaudin-1 is a member of the claudin family of proteins, which is composed of at least 24 members. Claudin proteins are integral membrane proteins with 4 transmembrane regions and 2 extracellular loops that form tight junctions. Tight junctions function as a channel and a barrier to maintain cellular morphology, polarity, and homeostasis between epithelial cells. Claudin-1 is a main component of tight junctions and is sorely responsible for normal barrier function of the skin. Misregulated expression of Claudin-1 has been shown to be associated with cancer progression and metastasis in several cancers. Claudin-1 has been found to be overexpressed in neoplasia associated with inflammatory bowel disease. Mutations in Claudin-1 gene lead to human skin diseases and Claudin-1 deficient mice die soon after birth due to dehydration.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Synthetic Claudin-1 peptide conjugated to KLH (TPRPYPKPAPSSGKDYVC)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This clone has no cross-reactivity with mouse (in house tested).\u003cbr\u003e\nRRID: AB_2687205 (BioLegend Cat. No. 697801) AB_2687191 (BioLegend Cat. No. 697802)\u003cbr\u003e\nStructure: 211 amino acids with a predicted molecular weight of 22.7 kD and observed approximately 18kD. Multi-pass membrane protein with 4 transmembrane domains.\u003cbr\u003e\nDistribution: Cell membrane. Cell junction.\u003cbr\u003e\nFunction: Claudin-1 is an integral membrane protein that forms tight junctions between skin epithelial cells to form barriers, regulate paracellular transport, and maintain cell polarity.\u003cbr\u003e\nInteraction: Forms homopolymers and heteropolymers with other claudin family proteins. Interacts with CLDN3, TJP1\/ZO-1, TJP2\/ZO-2, TJP3\/ZO-3, MPDZ, and PATJ.\u003cbr\u003e\nCell Type: Mesenchymal Stem Cells\u003cbr\u003e\nBiology Area: Stem Cells\u003cbr\u003e\nAntigen References: 1. Suh Y, et al. 2017. Oncogene. 36:1167. 2. Tokumasu R, et al. 2016. Proc. Natl. Acad. Sci. USA. 113:E4061. 3. Zhou B, et al. 2015. J. Clin. Med. 4:1960. 4. Saeedi BJ, et al. 2015. Mol. Biol. Cell. 26:2252. 5. Huang J, et al. 2015. Oncotarget. 6:1652. 6. Izraely S, et al. 2015. Int. J. Cancer. 136:1296.\u003cbr\u003e\nGene ID: 9076\u003cbr\u003e\nUniProt: View information about Claudin-1 on UniProt.org\u003cbr\u003e\nClone: 9E12C72\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Senescence-associated epithelial membrane protein, CLDN1, CLD1, SEMP1,\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864380625065,"sku":"697802","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-697802","provider":"Iright","version":"1.0","type":"link"}