{"product_id":"biolegend-698201","title":"Biolegend, 698201, Purified anti-CD106 (VCAM-1) Antibody, 25μg","description":"\u003cp\u003eCD106 is a glycosylphosphatidylinositol (GPI)-linked transmembrane protein, also known as VCAM-1 and INCAM-110. It is constitutively expressed on bone marrow stromal cells, myeloid progenitors, splenic dendritic cells, activated endothelial cells, as well as some lymphocytes. CD106 expression can be upregulated on endothelial cells by inflammatory cytokines. CD106 is involved in adhesion and acts as a counter-receptor for VLA-4 (α4\/β1 integrin) and LPAM-1 (α4\/β7 integrin).\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human recombinant VCAM-1\/FC\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.002 - 0.1 µg\/mL (1:5000-1:250000 diluted). It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Flaskamp L, et al. 2022. Cells. 11: . PubMed Heesters BA, et al. 2021. J Exp Med. 218:. PubMed\u003cbr\u003e\nRRID: AB_2687276 (BioLegend Cat. No. 698201) AB_2687285 (BioLegend Cat. No. 698202)\u003cbr\u003e\nStructure: Ig superfamily, 81 kD. Six N-glycosylation sites, apparent Mw is 90-110kD.\u003cbr\u003e\nDistribution: Plasma membrane of bone marrow stromal cells, myeloid progenitors, splenic dendritic cells, activated endothelial cells\u003cbr\u003e\nFunction: Important in cell-cell recognition. Function in leukocyte-endothelial cell adhesion.\u003cbr\u003e\nInteraction: Leukocytes\u003cbr\u003e\nLigand\/Receptor: VLA-4 (α4\/β1 integrin) and LPAM-1 (α4\/β7 integrin)\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology, Innate Immunity, Signal Transduction\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Kinashi T, et al. 1995. J. Leuko. Biol. 57:168. 3. Bevilacqua MP. 1993. Annu. Rev. Immunol. 11:767. 4. Koni PA, et al. 2001. J. Exp. Med. 193:741.\u003cbr\u003e\nGene ID: 7412\u003cbr\u003e\nUniProt: View information about CD106 on UniProt.org\u003cbr\u003e\nClone: A16047A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: INCAM-110, VCAM1, VCAM 1, Vascular cell adhesion protein 1, V-CAM 1,\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864394223785,"sku":"698201","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-698201","provider":"Iright","version":"1.0","type":"link"}