{"product_id":"biolegend-824002","title":"Biolegend, 824002, Purified anti-CX3CR1 Antibody (Previously Covance catalog# MMS-5067), 25microl","description":"\u003cp\u003eCX3CR1 is a G-protein-coupled seven-transmembrane chemokine receptor, also called GPR13 or V28. It is expressed on NK cells, T cell subset, monocytes\/macrophages, dendritic cells, some malignant epithelial cells, astrocytes, and microglial cells. CX3CL1 (known also as fractalkine and neurotactin) is the ligand of CX3CR1. CX3CL1 is a unique transmembrane molecule with a CX3C-motif chemokine domain and a mucin-like stalk. CX3CL1 is expressed by activated-endothelial cells, neurons, and astrocytes. The interaction of CX3CR1 and its ligand mediates cell adhesion and migration. CX3CL1 has been reported to play an important role in neuroinflammation and neurodegeneration.\u003cbr\u003e\n25microl\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: This monoclonal antibody was raised against a peptide sequence conjugated to KLH corresponding to amino acids 207-222 of the human CX3CR1 protein.\u003cbr\u003e\nFormulation: Phosphate-buffered solution.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 1.0 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: This antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label or CoA to find the proper storage conditions.\u003cbr\u003e\nApplication: IHC-P - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 10.0 - 20.0 µg\/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This antibody is effective in formalin-fixed paraffin-embedded immunohistochemical staining (IHC-P).\u003cbr\u003e\nProduct Citations: Zhan L, et al. 2024. Cell Commun Signal. 457:22. PubMed Pal B, et al. 2021. EMBO J. 40:e107333. PubMed Ahn JH, et al. 2019. Int J Mol Med. 44:939. PubMed Taylor JG, et al. 2022. Haematologica. :. PubMed\u003cbr\u003e\nRRID: AB_2734592 (BioLegend Cat. No. 824002) AB_2564876 (BioLegend Cat. No. 824001)\u003cbr\u003e\nStructure: Expected MW: 50 kD\u003cbr\u003e\nBiology Area: Cell Biology, Neuroinflammation, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: Cytokine\/Chemokine Receptors, GPCR\u003cbr\u003e\nGene ID: 1524\u003cbr\u003e\nUniProt: View information about CX3CR1 on UniProt.org\u003cbr\u003e\nClone: 8E10.D9\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CX3C chemokine receptor 1, fractalkine receptor, beta chemokine receptor-like 1, chemokine (C-C) receptor-like 1, GRP13, V28\u003cbr\u003e\nPreviously: Covance Catalog# MMS-5067\u003cbr\u003e\nIsotype: Mouse IgG1, λ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862493876393,"sku":"824002","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-824002","provider":"Iright","version":"1.0","type":"link"}