{"product_id":"biolegend-824004","title":"Biolegend, 824004, Biotin anti-CX3CR1 Antibody, 100μg","description":"\u003cp\u003eCX3C chemokine receptor 1 (CX3CR1) also known as fractalkine receptor or G-protein coupled receptor 13, is a receptor that binds the chemokine CX3CL1. CX3CR1 expression is associated with T cells, NK cells, and brain microglia. CX3CL1 is a unique transmembrane molecule with a CX3C-motif chemokine domain and a mucin-like stalk. CX3CL1 is expressed by activated-endothelial cells, neurons, and astrocytes. The interaction of CX3CR1 and its ligand mediates cell adhesion and migration. CX3CL1 has been reported to play an important role in neuroinflammation and neurodegeneration.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: This monoclonal antibody was raised against a peptide sequence conjugated to KLH corresponding to amino acids 207-222 of the human CX3CR1 protein.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.\u003cbr\u003e\nApplication: IHC-P - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration of 20 µg\/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This antibody is effective in Immunoblotting (WB) and immunohistochemistry (IHC) for the relevant formats of this clone.\u003cbr\u003e\nRRID: AB_2650684 (BioLegend Cat. No. 824004)\u003cbr\u003e\nStructure: CX3CR1 is a 355 amino acid G-protein coupled receptor, 7 transmembrane regions protein with a molecular mass of 40 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: central nervous system, and blood. Cellular Distribution: plasma membrane.\u003cbr\u003e\nFunction: CX3CR1 is involved in cell recruitment during inflammation, and participates in cell adhesion and extravasation from blood vessels. It is also known as a coreceptor for HIV1.\u003cbr\u003e\nLigand\/Receptor: CX3CL1 (fractalkine, neurotactin).\u003cbr\u003e\nBiology Area: Cell Biology, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: Cytokine\/Chemokine Receptors, GPCR\u003cbr\u003e\nAntigen References: 1. Chen P, et al. 2016. BioMed. Res. Int. 2016. 8090918. PubMed 2. Sheridan GK, Murphy KJ. 2013. Open Biol. 3 (12) 130181. PubMed\u003cbr\u003e\nGene ID: 1524\u003cbr\u003e\nUniProt: View information about CX3CR1 on UniProt.org\u003cbr\u003e\nClone: 8E10.D9\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CX3C chemokine receptor 1, fractalkine receptor, beta chemokine receptor-like 1, chemokine (C-C) receptor-like 1, GRP13, V28\u003cbr\u003e\nIsotype: Mouse IgG1, λ\u003cbr\u003e\nQ: How many biotin molecules are per antibody structure?\u003cbr\u003e\nA: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862493810857,"sku":"824004","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-824004","provider":"Iright","version":"1.0","type":"link"}