{"product_id":"biolegend-830501","title":"Biolegend, 830501, Purified anti-mouse CD18 Antibody (Previously Covance catalog# MRT-5214), 100microl","description":"\u003cp\u003eCD18 is a 95 kD protein, also known as integrin β 2 subunit. It is expressed on all leukocytes. CD18, in association with integrin α chain CD11a, CD11b, and CD11c forms LFA-1, Mac-1, and α X β 2 , respectively, and plays an important role in leukocytes adhesion. The CD18 integrin complexes bind ICAM-1 (CD54), ICAM-2 (CD102), ICAM-3 (CD50), iC3b, and fibrinogen. The M18\/2 antibody is able to block tumor cell metastasis and enhance cell adhesion.\u003cbr\u003e\n100microl\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: This monoclonal antibody was raised against cell membrane glycoproteins derived from T-cell lymphoma BW5147 cells.\u003cbr\u003e\nFormulation: Phosphate-buffered solution.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 1 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: This antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label or CoA to find the proper storage conditions.\u003cbr\u003e\nApplication: FC\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The optimal working dilution should be determined for each specific assay condition. • FC: 1:1000 - 1:10,000*\u003cbr\u003e\nApplication Notes: This antibody is effective in flow cytometry (FC). *FC Positive Control: Mouse blood Rat IgG2a Isotype antibody available: Catalog number: 910601\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Trowbridge IS, et al. Molecular Complexity of Leukocyte Surface Glycoproteins Related to the Macrophage Differentiation Antigen MAC-1. J. Exp. Med. 154: 1517-1524, November 1981.\u003cbr\u003e\nRRID: AB_2564939 (BioLegend Cat. No. 830501)\u003cbr\u003e\nBiology Area: Cell Biology, Complement, Neuroinflammation, Neuroscience\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Anderson DC, et al. 1987. Annu. Rev. Med. 38:175. 3. Wilson RW, et al. 1993. J. Immunol. 151:1571.\u003cbr\u003e\nGene ID: 16414\u003cbr\u003e\nUniProt: View information about CD18 on UniProt.org\u003cbr\u003e\nClone: C71\/16\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Integrin beta-2, Mac-1 beta, macrophage antigen-1 beta, complement receptor C3 subunit beta, lymphocyte function associated antigen 1, cell surface adhesion glycoproteins LFA-1\/CR3\/p150,95 subunit beta, 2E6, LAD, Cd18, Lfa1, MF17, LCAMB, AI528527\u003cbr\u003e\nPreviously: Covance Catalog# MRT-5214\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862951481513,"sku":"830501","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-830501","provider":"Iright","version":"1.0","type":"link"}