{"product_id":"biolegend-846201","title":"Biolegend, 846201, Purified anti-PINK1 Antibody, 25μg","description":"\u003cp\u003ePINK1 (PTEN-induced putative kinase 1) is a 63 kD mitochondrial transmembrane protein that is often cleaved by PARL into a 53 kD fragment. The protein is involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). PINK1 phosphorylation of mitochondrial proteins can protect against mitochondrial dysfunction due to cellular stresses. PINK1 mutations can cause autosomal recessive early-onset Parkinson disease.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 5.0 - 10 µg per mL. For immunocytochemistry, a concentration range of 1.0 - 5.0 μg\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Lin Q, et al. 2020. JCI Insight. :5. PubMed Fiesel FC, et al. 2023. Autophagy. 1711:19. PubMed Yao J, et al. 2022. Autophagy. 18:1879. PubMed Bharath LP, et al. 2020. Cell Metabolism. 32(1):44-55.e6.. PubMed Chung E, et al. 2020. Sci Adv. 6:eaba1193. PubMed\u003cbr\u003e\nRRID: AB_2783414 (BioLegend Cat. No. 846201) AB_2572127 (BioLegend Cat. No. 846202)\u003cbr\u003e\nStructure: PINK1 is a 581 amino acid, 63 kD, transmembrane protein that contains an N-terminal mitochondrial localization sequence, a serine\/threonine kinase domain, and a C-terminal regulatory domain. PINK1 is proteolytically cleaved by PARL into a 55 kD fragment.\u003cbr\u003e\nDistribution: Mitochondria and cytoplasm.\u003cbr\u003e\nFunction: PINK1 is involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of Parkin protein (PARK2). PARL-cleaved PINK1 is a cytoplasmic probe for damaged mitochondria. PINK1 phosphorylation of mitochondrial proteins can protect against mitochondrial dysfunction due to cellular stresses.\u003cbr\u003e\nInteraction: PARKIN, Beclin 1, FBX07, DJ-1, HSP90\/CDC37.\u003cbr\u003e\nLigand\/Receptor: PARKIN, Beclin 1, FBX07, DJ-1, HSP90\/CDC37.\u003cbr\u003e\nBiology Area: Cell Biology, Mitochondrial Function, Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Protein Trafficking and Clearance\u003cbr\u003e\nMolecular Family: Mitochondrial Markers\u003cbr\u003e\nAntigen References: 1. Trempe JF, Fon EA. 2013. Front Neurol. 4:38. 2. Durcan TM, Fon EA. 2015. Genes Dev. 29(10):989.\u003cbr\u003e\nGene ID: 65018\u003cbr\u003e\nUniProt: View information about PINK1 on UniProt.org\u003cbr\u003e\nClone: DU46-1.1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: PTEN induced putative kinase 1, BRPK, PARK6, Serine\/threonine-protein kinase PINK1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46863030911145,"sku":"846201","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-846201","provider":"Iright","version":"1.0","type":"link"}