{"product_id":"biolegend-852002","title":"Biolegend, 852002, Purified anti-TFEB Antibody, 100μg","description":"\u003cp\u003eThe autophagy-lysosomal pathway is involved in the degradation of long-lived proteins. The transcription factor EB (TFEB) plays a critical role in regulating basic cellular processes, such as lysosomal biogenesis and autophagy. The subcellular localization and activity of TFEB are regulated by mechanistic target of rapamycin (mTOR)-mediated phosphorylation. TFEB is also involved in physiological processes, and it induces the intracellular clearance of pathogenic factors in a variety of diseases, such as Parkinson's and Alzheimer's, suggesting that novel therapeutic strategies could be based on the modulation of TFEB activity.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedIHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 5.0 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 5 - 10 µg\/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2728585 (BioLegend Cat. No. 852001) AB_2728586 (BioLegend Cat. No. 852002)\u003cbr\u003e\nStructure: TFEB is a 476 amino acid protein with a molecular weight mass of approximately 53kD.\u003cbr\u003e\nDistribution: Tissue distribution: TFEB is expressed in numerous cell types of the central nervous system (CNS). Cellular distribution: Cytosolic and nucleus.\u003cbr\u003e\nFunction: TFEB is a major regulator of autophagy and lysosomal biogenesis.\u003cbr\u003e\nInteraction: TFEB interacts with the mTOR complex and its activity is thought to be regulated through the phosphorylation by mTOR.\u003cbr\u003e\nBiology Area: Cell Biology, Neurodegeneration, Neuroscience, Neuroscience Cell Markers, Protein Trafficking and Clearance, Transcription Factors\u003cbr\u003e\nMolecular Family: Nuclear Markers\u003cbr\u003e\nAntigen References: Martini-Stoica H, et al. 2016. Trends Neurosci. 221-234. Napolitano G, Ballabio A. 2016. J. Cell Sci. 129: 2475-81. Raben N, Puertollano R. 2016. Annu. Rev. Cell Dev. Biol. 32: 255-278.\u003cbr\u003e\nGene ID: 7942\u003cbr\u003e\nUniProt: View information about TFEB on UniProt.org\u003cbr\u003e\nClone: A17106C\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Transcription factor EB\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866051236009,"sku":"852002","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-852002","provider":"Iright","version":"1.0","type":"link"}