{"product_id":"biolegend-852102","title":"Biolegend, 852102, Purified anti-Sortilin Antibody, 100μg","description":"\u003cp\u003eSortilin was originally purified from human brain tissue and was identified as a new lipoprotein receptor, which was later identified as a multifunctional sorting receptor of the VPS10P-domain receptor family. Although Sortilin is predominately expressed in neurons of the central and the peripheral nervous systems, it is also expressed in metabolic tissues including liver. Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is critical for lipid metabolism, and it has been implicated in lipid disorders. Sortilin is also an APOE receptor implicated in Alzheimer disease.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Human SORT1 recombinant protein (327-638 a.a.) expressed in E. coli.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedIHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg per ml. For immunohistochemistry, a concentration range of 2.0 - 5.0 µg\/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2728587 (BioLegend Cat. No. 852101) AB_2728588 (BioLegend Cat. No. 852102)\u003cbr\u003e\nStructure: Sortilin is an 831 amino acid protein with a molecular mass of 95 kD.\u003cbr\u003e\nDistribution: Tissue distribution: Sortilin is expressed in numerous tissues including brain, spinal cord, heart, skeletal muscle, thyroid, placenta, and testis. Cellular distribution: Plamsa membrane, cytosol, endosome, endoplasmic reticulum, lysosome, and golgi apparatus.\u003cbr\u003e\nFunction: Sortilin functions as a cell surface receptor and mediates intracellular trafficking of diverse endogenous or exogenous protein substrates between the trans-Golgi network and plasma membrane compartments.\u003cbr\u003e\nInteraction: Sortilin interacts with p75 Neurotrophin Receptor and is localized together with the golgi marker GM130 and the early endosome marker EEA1.\u003cbr\u003e\nLigand\/Receptor: Sortilin functions as lipoprotein receptor for neurotrophins and other growth factors.\u003cbr\u003e\nBiology Area: Cell Biology, Neurodegeneration, Neuroscience, Neuroscience Cell Markers, Protein Trafficking and Clearance, Transcription Factors\u003cbr\u003e\nMolecular Family: Golgi Markers\u003cbr\u003e\nAntigen References: Skeldal S, et al. 2012. J. Biol. Chem. 287:43798-809. Herda S, et al. 2012. Immunity. 37:854-66. Gao A, et al. 2017. DNA Cell Biol. 36:1050-1061. Carlo AS. 2013. Prion. 7:378-82.\u003cbr\u003e\nGene ID: 6272\u003cbr\u003e\nUniProt: View information about Sortilin on UniProt.org\u003cbr\u003e\nClone: W16078A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: 100 kD NT receptor\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866303451305,"sku":"852102","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-852102","provider":"Iright","version":"1.0","type":"link"}