{"product_id":"biolegend-855901","title":"Biolegend, 855901, Purified anti-RAGE Antibody, 25μg","description":"\u003cp\u003eRAGE (receptor for advanced glycation end products), is a member of the immunoglobulin super family of proteins with a molecular weight estimated at ~35 kD. RAGE is a pattern recognition receptor as it recognizes a common structure of a class of ligands, including HMGB1, S10012, S100B, S100A7, and amyloid precursor protein (APP).  RAGE may play a role in the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease (AD). Increased RAGE expression levels have been observed in neurons and microglia surrounding senile plaques. In addition, RAGE can mediate the transport of amyloid beta across the blood-brain barrier and its accumulation in the brain.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant Human RAGE\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedIHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. For immunohistochemistry, a concentration range of 5.0 - 10 µg\/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2783446 (BioLegend Cat. No. 855901) AB_2783447 (BioLegend Cat. No. 855902)\u003cbr\u003e\nStructure: RAGE is a 404 amino acid protein with an apparent molecular mass of ~43 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Lung (major) and colon (less expressed) Cellular Distribution: Plasma membrane, extracellular, and nucleus\u003cbr\u003e\nFunction: Functions as a pattern recognition receptor in the innate immune system that initiates proinflammatory responses.\u003cbr\u003e\nInteraction: RAGE forms homo-dimers, and interacts with HMGB1, S100A1, APP, S100B, S100A12, and S100A14.\u003cbr\u003e\nLigand\/Receptor: AGEs (advanced glycation end-products)\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience\u003cbr\u003e\nAntigen References: Barbezier N, et al. 2014. Ann. Biol. Clin. (Paris) 72:669. Kalea AZ, et al. 2009. Clin. Sci. (Lond) 116:621.\u003cbr\u003e\nGene ID: 177\u003cbr\u003e\nUniProt: View information about RAGE on UniProt.org\u003cbr\u003e\nClone: A17158D\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: RAGE, AGER, Advanced glycosylation end product-specific receptor\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866052186281,"sku":"855901","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-855901","provider":"Iright","version":"1.0","type":"link"}