{"product_id":"biolegend-856001","title":"Biolegend, 856001, Purified anti-Dopamine Receptor D1 Antibody, 25μg","description":"\u003cp\u003eThe D1 subtype of the dopamine receptor (DRD1) is a Gs\/a-protein coupled receptor mainly expressed in the caudate putamen of the central nervous system. Upon binding to its ligand, DRD1 indirectly activates cyclic AMP-dependent protein kinase and regulates neuronal development. Two transcript variants, DRD1a and DRD1b exist in vivo. DRD1 has been discovered to modulate DRD2-mediated signaling pathway. DRD1 and DRD2 also form heterodimers via C-terminal regions, which has been reported to be involved in phospholipase C and CaMKII activation, and BDNF production.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human DRD1\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested IHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 10 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 5.0 - 10 µg\/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2783448 (BioLegend Cat. No. 856001) AB_2783449 (BioLegend Cat. No. 856002)\u003cbr\u003e\nStructure: DRD1 is a 446 amino acid protein with an apparent molecular mass of ~ 49 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Mainly expressed in the midbrain. Cellular Distribution: Plasma membrane.\u003cbr\u003e\nFunction: DRD1 is involved in dopamine related signaling and neuronal development.\u003cbr\u003e\nInteraction: Interacts with DRD2, DNAJC14, and DRD1IP.\u003cbr\u003e\nLigand\/Receptor: Receptor of Dopamine\u003cbr\u003e\nBiology Area: Cell Biology, Neuroscience, Neuroscience Cell Markers, Synaptic Biology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, GPCR\u003cbr\u003e\nAntigen References: Amare AT, et al. 2017. EPMA J. 8(3):211 Arango-Lievano M, et al. 2015. Med Sci (Paris). 31(5):546 Serretti A, et al. 2007. J Alzheimers Dis. 12(1):73\u003cbr\u003e\nGene ID: 181213488\u003cbr\u003e\nUniProt: View information about Dopamine Receptor D1 on UniProt.org\u003cbr\u003e\nClone: A17050E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: DRD1, Dopamine Receptor D1\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864405856425,"sku":"856001","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-856001","provider":"Iright","version":"1.0","type":"link"}