{"product_id":"biolegend-856401","title":"Biolegend, 856401, Purified anti-VPS35 Antibody, 25μg","description":"\u003cp\u003eVPS35 is the largest subunit of the retromer complex, which plays an important role in retrograde protein transport from the endosome to the trans-Golgi network. VPS35 binds to VPS26 (VPS26A or VPS26B) and VPS29 to form the vacuolar protein sorting subcomplex (VPS), which in turn interacts with different nexins to form different retromer variants that transport different targets. D620N mutation in VPS35 has been implicated as a causative genetic factor for developing late-onset, autosomal dominant familial Parkinson’s disease, and could serve as potential therapeutic target for PD.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2783456 (BioLegend Cat. No. 856401) AB_2783457 (BioLegend Cat. No. 856402)\u003cbr\u003e\nStructure: VPS35 is a 796 amino acid protein with an apparent molecular mass of ~92 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Ubiquitously expressed in all tissues. Cellular Distribution: Cytosol, lysosome, endosome, and secreted.\u003cbr\u003e\nFunction: Largest subunit of the retromer complex involved in retrograde transport of proteins from endosomes to the trans-Golgi network.\u003cbr\u003e\nInteraction: VPS26 (VPS26A or VPS26B), VPS29, SNX1, SNX2, IGF2R, SNX3, GOLPH3, LRRK2, SLC11A2, SNX27, RAB7A.\u003cbr\u003e\nBiology Area: Cell Biology, Mitochondrial Function, Neurodegeneration, Neuroscience, Protein Trafficking and Clearance\u003cbr\u003e\nMolecular Family: Organelle Markers\u003cbr\u003e\nAntigen References: Cui Y, et al. 2018. FEBS Lett. 592(7):1096 Williams ET, et al. 2017. J Parkinsons dis. 7(2):219 Ferreira M, et al. 2017. Acta Neurol Scand. 135(3):273\u003cbr\u003e\nGene ID: 557376511425479\u003cbr\u003e\nUniProt: View information about VPS35 on UniProt.org\u003cbr\u003e\nClone: A17084A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Vacuolar protein sorting-associated protein 35\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866050973865,"sku":"856401","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-856401","provider":"Iright","version":"1.0","type":"link"}