{"product_id":"biolegend-856701","title":"Biolegend, 856701, Purified anti-PAK1 Antibody, 25μg","description":"\u003cp\u003ePAK1 is a ubiquitously expressed protein that belongs to the group I PAK family of serine\/threonine kinases, which are important mediators that link the Rho family GTPase signaling to cytoskeleton remodeling. PAK1 activation has been shown to play a role in tumorgenesis, actin dynamics, cell cycle progression, cell motility, and angiogenesis. The PAK family of kinases is affected in several brain diseases, including neurofibromatosis model of autism, Alzheimer’s Disease, Fragile X syndrome and schizophrenia 1 . Recently studies using electrophysiological recordings of hippocampal CA1 synaptic currents suggest that PAK1 plays a role in inhibitory synaptic transmission, where knocking out PAK affects the excitatory\/inhibitory balance in the hippocampus, and may lead to dysregulation of synaptic strength.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedIHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 0.2 - 2.0 µg\/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2783462 (BioLegend Cat. No. 856701)\u003cbr\u003e\nStructure: PAK1 is a 545 amino acid protein with an apparent molecular mass of ~ 61 kD.\u003cbr\u003e\nDistribution: Tissue distribution: Ubiquitously expressed in all tissues. Cellular distribution: Cytosol, plasma membrane, and nucleus.\u003cbr\u003e\nFunction: PAK1 plays an important role in regulating cytoskeletal dynamics, spine morphology, and synaptic plasticity.\u003cbr\u003e\nInteraction: Forms homodimer, NISCH, DVL1, MUSK, CDC2L1, CDC2L2, p110C, CDC42\/P21, RAC1, DSCAM, PDPK1, RAF1, NCK1, NCK2\u003cbr\u003e\nCell Type: Astrocytes, Microglia, Neurons, Oligodendrocytes\u003cbr\u003e\nBiology Area: Neuroscience, Synaptic Biology\u003cbr\u003e\nMolecular Family: Postsynaptic proteins\u003cbr\u003e\nAntigen References: Xia S, et al. 2018. Small GTPases. 9(4):322 Kreis P, et al. 2009. Cell Signal. 21(3):384 Nikolic M. 2008. Mol Neurobiol. 37(2-3): 187 Salminen A, et al. 2008. Biochem Biophys Res Commun. 371(4):587\u003cbr\u003e\nGene ID: 50581847929431\u003cbr\u003e\nUniProt: View information about PAK1 on UniProt.org\u003cbr\u003e\nClone: A17137A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: PAK1, p21-activated kinase 1\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866052120745,"sku":"856701","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-856701","provider":"Iright","version":"1.0","type":"link"}