{"product_id":"biolegend-862505","title":"Biolegend, 862505, Biotin anti-HNRNPA1 Antibody, 25μg","description":"\u003cp\u003eHeterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a multi-purpose RNA binding protein involved in RNA metabolism and DNA genomic stability in normal and pathological conditions. hnRNP A1 is ubiquitously expressed and usually associates with nascent RNA polymerase II transcripts. hnRNP A1 is  abundantly expressed in neuronal cells and reproductive tissue. Loss of hnRNP A1 has been observed in several neurodegenerative diseases, including Alzheimer’s disease, multiple sclerosis, amytrophic lateral sclerosis. Structurally, hnRNPA1 has two RNA recognition motifs, which are post-translationally modified to alter its nuclear pore shuttling properties and RNA interaction.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Partially purified HeLa HNRNPA1 protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.\u003cbr\u003e\nApplication: IHC-P - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 0.1 - 2.5 µg\/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2814595 (BioLegend Cat. No. 862505) AB_2814596 (BioLegend Cat. No. 862506)\u003cbr\u003e\nStructure: hnRNPA1 has two isoforms. Human HNRPNA1 isoform A1-A is a 320 amino acid protein with a molecular mass of 34 kD, and isoform A1-B is a 372 amino acid protein with a molecular mass of 38 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Ubiquitous expression Cellular Source: Nucleus and cytoplasm\u003cbr\u003e\nFunction: RNA metabolism, genomic stability\u003cbr\u003e\nInteraction: Nascent RNA polymerase II transcripts\u003cbr\u003e\nCell Type: Neurons\u003cbr\u003e\nBiology Area: Neurodegeneration, Neuroscience, Protein Synthesis\u003cbr\u003e\nAntigen References: Bekenstein U, et al. 2013. Mol Cell Neurosci. 56:436-46. Jean-Philippe J, et al. 2014. Biochim Biophys Acta. 1839(4): 251–258.\u003cbr\u003e\nGene ID: 31781538229578\u003cbr\u003e\nUniProt: View information about HNRNPA1 on UniProt.org\u003cbr\u003e\nClone: 4B10\/HNRNPA1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Heterogeneous nuclear ribonucleoprotein A1, hnRNP A1, Helix-destabilizing protein, Single-strand RNA-binding protein, hnRNP core protein A1\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003cbr\u003e\nQ: How many biotin molecules are per antibody structure?\u003cbr\u003e\nA: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862409040041,"sku":"862505","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-862505","provider":"Iright","version":"1.0","type":"link"}