{"product_id":"biolegend-862802","title":"Biolegend, 862802, Purified anti-SMN (Gemin 1) Antibody, 100μg","description":"\u003cp\u003eSMN1\/Gem-associated protein 1 (Gemin 1) is a component of the survival of motor neurons (SMN) macromolecule protein complex, which plays an important role in the assembly and re-structuring of small nucleoproteins and transcriptosomes. The SMN complex localizes to the cytosol and nucleus of eukaryotic cells. Mutations of SMN1 lead to spinal muscular atrophy.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedICC, IHC-F - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Kobayashi M, et al. 2017. Disease Models \u0026amp; Mechanisms. (10):215 (IHC-F) Spiro Z, et al. 2016. Scientific Reports. (6):27470 (ICC) Yong J, et al. 2004. Molecular and Cellular Biology. 24(7):2747 (WB)\u003cbr\u003e\nRRID: AB_2810753 (BioLegend Cat. No. 862801) AB_2810754 (BioLegend Cat. No. 862802)\u003cbr\u003e\nStructure: SMN1 is a 294 amino acid protein with an apparent molecular mass of ~ 32 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Brain, pancreas, gallbladder, bladder, testis, lymph node, and bone marrow Cellular Distribution: Nucleus and cytosol\u003cbr\u003e\nFunction: SMN1 is a component of the SMN complex essential for the formation of snRNP complexes in Eukaryotic cells.\u003cbr\u003e\nInteraction: SMN1 forms homodimers or found in complex with other SMN\/GEMIN proteins.\u003cbr\u003e\nCell Type: Neurons\u003cbr\u003e\nBiology Area: Chromatin Remodeling\/Epigenetics, Neurodegeneration, Neuroscience, Synaptic Biology, Transcription Factors\u003cbr\u003e\nAntigen References: Maretina MA, et al. 2018. Curr Genomics. 19(5):339 Singh RN, et al. 2018. Adv Neurobiol. 20:31 Groen EJN, et al. 2018. Nat Rev Neurol. 14(4):214\u003cbr\u003e\nGene ID: 66066607\u003cbr\u003e\nUniProt: View information about SMN on UniProt.org\u003cbr\u003e\nClone: 2B1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: SMN1, SMN, SMN2, SMNT, GEMIN1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866540265641,"sku":"862802","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-862802","provider":"Iright","version":"1.0","type":"link"}