{"product_id":"biolegend-862902","title":"Biolegend, 862902, Purified anti-Gemin 2 Antibody, 100μg","description":"\u003cp\u003eGemin 2 is a component of the survival of motor neurons (SMN) macromolecule protein complex, which plays an important role in the assembly and re-structuring of small nucleoproteins and transcriptosomes. The SMN complex localizes to the cytosol and nucleus of eukaryotic cells. Gemin 2 is the only gemin protein that has no homology to any other gemins. Recent studies have suggested that the role of Gemin 2 is to organize 5 Sm proteins into a partial ring for snRNA binding.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedICC - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2.0 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Battle D, et al. 2007. J Biol Chem. 282(38):27953 (WB, ICC)\u003cbr\u003e\nProduct Citations: Bizen N, et al. 2022. Cell Death Differ. . PubMed\u003cbr\u003e\nRRID: AB_2810755 (BioLegend Cat. No. 862901) AB_2810756 (BioLegend Cat. No. 862902)\u003cbr\u003e\nStructure: Gemin 2 is a 280 amino acid protein with an apparent molecular mass of ~ 32 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Brain, skeletal muscle, gallbladder, and testis Cellular Distribution: Nuclear and cytosol\u003cbr\u003e\nFunction: Gemin 2 is a component of the SMN complex that is essential for the formation of snRNP complexes. It organizes 5 Sm proteins into a partial ring for snRNA binding.\u003cbr\u003e\nInteraction: Gemin 2 binds to SM proteins and is found in complex with other SMN\/GEMIN proteins.\u003cbr\u003e\nCell Type: Neurons\u003cbr\u003e\nBiology Area: Chromatin Remodeling\/Epigenetics, Neurodegeneration, Neuroscience, Synaptic Biology, Transcription Factors\u003cbr\u003e\nAntigen References: Battle D, et al. 2007. J Biol Chem. 282(38):27953 Gupta K, et al. 2015. J Biol Chem. 290(33):20185\u003cbr\u003e\nGene ID: 84876660384404\u003cbr\u003e\nUniProt: View information about Gemin 2 on UniProt.org\u003cbr\u003e\nClone: 2S7\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: GEMIN 2, SIP1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862331314345,"sku":"862902","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-862902","provider":"Iright","version":"1.0","type":"link"}