{"product_id":"biolegend-863801","title":"Biolegend, 863801, Purified anti-LBP Antibody, 25μg","description":"\u003cp\u003eLPS-binding protein (LBP) is a protein that binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), which is a glycolipid present in the outer membrane of all Gram-negative bacteria. It is involved in the immunological response to infections of Gram-negative bacteria, together with bactericidal permeability-increasing protein (BPI). LBP also interacts with the CD14 receptor and enhances its association with LPS. LBP is associated with diseases including bacterial sepsis, and is related to cytokine release in response to bacteria in immune system.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Polyclonal\u003cbr\u003e\nHost Species: Rabbit\u003cbr\u003e\nImmunogen: Recombinant LBP expressed in E.coli.\u003cbr\u003e\nFormulation: 0.01 M PBS, pH 7.4, containing 0.02% NaN3, 50% glycerol.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: Store at 4°C for up to 3 months. For longer term storage, aliquot into small volumes and store at -20°C.\u003cbr\u003e\nApplication: WB - Quality testedIHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 1.0 µg\/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Heymann CJF, et al. 2022. J Bone Oncol. 36:100451. PubMed Heymann CJF, et al. 2021. Cancer Lett. 522:63. PubMed\u003cbr\u003e\nRRID: AB_2820150 (BioLegend Cat. No. 863801)\u003cbr\u003e\nStructure: LBP is a 481 amino acid protein with an apparent molecular mass of ~53 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Brain, kidney, lung, and immune system Cellular Distribution: Extracellular, nucleus, and membrane\u003cbr\u003e\nFunction: Innate immune response\u003cbr\u003e\nInteraction: LPS, BPI, CD14 receptor\u003cbr\u003e\nCell Type: Mesenchymal cells, Monocytes, Neurons\u003cbr\u003e\nBiology Area: Bacterial proteins and Toxins, Cell Biology, Immunology, Neurodegeneration, Neuroscience\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: Pretorius E, et al. 2018. PLoS One. 13(3): e0192121. Sakura T, et al. 2017. Cardiovasc Diabetol. 16(1):62. Worthmann H, et al. 2015. J Neuroinflammation. 12:13.\u003cbr\u003e\nGene ID: 39291680329469\u003cbr\u003e\nUniProt: View information about LBP on UniProt.org\u003cbr\u003e\nClone: Poly28638\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: LPS-Binding Protein, Lipopolysaccharide Binding Protein, Lipopolysaccharide-Binding Protein, BPI Fold Containing Family D, Member 2, BPIFD2\u003cbr\u003e\nIsotype: Rabbit Polyclonal IgG\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866466668713,"sku":"863801","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-863801","provider":"Iright","version":"1.0","type":"link"}