{"product_id":"biolegend-865302","title":"Biolegend, 865302, Purified anti-Cofilin 1 Antibody, 100μg","description":"\u003cp\u003eCofilin 1 is a ubiquitously expressed actin-regulating protein that binds to and depolymerizes filamentous actin (F-actin), as well as inhibits G-actin polymerization in a pH-dependent mechanism. Cofilin 1 plays a major role in cell migration, particularly tumor cell migration and invasion. A recent study using colorectal cancer as model, compared expression of cofilin 1 in cancer tissue and adjacent non-tumor tissue and suggested that it may be used as a novel diagnostic tumor marker in various cancers 4 .\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human CFL1 recombinant protein (a.a. Met 1 - Leu 166)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedIHC-P, ICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2.0 - 10 µg per mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 5.0 µg\/mL is suggested. For immunocytochemistry, a concentration range of 2.0 - 10 μg\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: For WB on brain lysates, 5 - 10 µg\/mL is recommended.\u003cbr\u003e\nRRID: AB_2810771 (BioLegend Cat. No. 865301) AB_2810772 (BioLegend Cat. No. 865302)\u003cbr\u003e\nStructure: Cofilin 1 is a 166 amino acid protein with an apparent molecular mass of ~19 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Immune system, gastrointestinal tract, lung, testis, and skin Cellular Distribution: Nucleus, cytosol, plasma membrane, cytoskeleton, and mitochondrion\u003cbr\u003e\nInteraction: Cofilin 1 plays a role in cytoskeleton dynamics by regulating F-actin depolimerization\u003cbr\u003e\nLigand\/Receptor: HSPH1, LIMK1, F-actin\u003cbr\u003e\nCell Type: Astrocytes, Dopaminergic Neurons, GABAergic Neurons, Glutamatergic Neurons, Mature Neurons, Microglia, Neural Stem Cells, Neurons, Oligodendrocytes\u003cbr\u003e\nBiology Area: Cancer Biomarkers, Cell Biology, Cell Motility\/Cytoskeleton\/Structure, Cell Proliferation and Viability, Cell Structure, Neurodegeneration, Neuroscience, Synaptic Biology\u003cbr\u003e\nMolecular Family: Cytoskeletal Proteins, GTPases, Scaffold Proteins\u003cbr\u003e\nAntigen References: Kanellos G and Frame MC. 2016. J Cell Sci. 129(17):3211 Walsh KP, et al. 2014. Prion. 8(6):375 Xu P, et al. 2018. Front Plant Sci. 9:1528 Mousavi S, et al. 2018. J Gastrointest Oncol. 9(5):791\u003cbr\u003e\nGene ID: 10721263129271\u003cbr\u003e\nUniProt: View information about Cofilin 1 on UniProt.org\u003cbr\u003e\nClone: A18040J\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Cofilin 1, CFL1, CFL\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866059591849,"sku":"865302","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-865302","provider":"Iright","version":"1.0","type":"link"}