{"product_id":"biolegend-865602","title":"Biolegend, 865602, Purified anti-Parkin Antibody, 100μg","description":"\u003cp\u003eParkin (also known as PARK2, AR-JP, PRKN) is a protein encoded by the PARK2 gene in humans. It is a component of the E3 ubiquitin ligase complex that mediates the targeting of proteins for degradation. Mutations in the PARK2 gene cause a familial form of Parkinson’s disease called autosomal recessive juvenile Parkinson’s disease (AR-JP).\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 5.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2810777 (BioLegend Cat. No. 865601) AB_2810778 (BioLegend Cat. No. 865602)\u003cbr\u003e\nStructure: Parkin is a 465 amino acid protein with an apparent molecular mass of ~ 52 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Brain, heart, testis, and skeletal muscle. Cellular Distribution: Cytosol, mitochondria, nucleus, and endoplasmic reticulum.\u003cbr\u003e\nFunction: Parkin in involved in protein ubiquitination, protein degradation, mitochondria function, and neurodegeneration.\u003cbr\u003e\nInteraction: Ubiquitin, PINK1\u003cbr\u003e\nLigand\/Receptor: BCL2, SYT11, CCNE1, GPR37, RHOT1\/MIRO1, MFN1\u003cbr\u003e\nCell Type: Astrocytes, Microglia, Neurons, Oligodendrocytes\u003cbr\u003e\nBiology Area: Cell Biology, Mitochondrial Function, Neurodegeneration, Neuroinflammation, Protein Misfolding and Aggregation, Ubiquitin\/Protein Degradation\u003cbr\u003e\nMolecular Family: Enzymes and Regulators, Ligases\u003cbr\u003e\nAntigen References: Tay SP, et al. 2018. J Biol Chem. 285: 29231-29238. Pawlyk AC, et al. 2003. J Biol Chem. 278(48):48120-8.\u003cbr\u003e\nGene ID: 5071\u003cbr\u003e\nUniProt: View information about Parkin on UniProt.org\u003cbr\u003e\nClone: 5C3\/Parkin\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: PARK2, AR-JP, LPRS2, PDJ, PRKN, E3 ubiquitin-protein ligase parkin, Parkin 2, E3 ubiquitin ligase, parkinson disease protein 2, parkinson juvenile disease protein 2, Parkinson disease (autosomal recessive, juvenile) 2\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864163635369,"sku":"865602","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-865602","provider":"Iright","version":"1.0","type":"link"}