{"product_id":"biolegend-866202","title":"Biolegend, 866202, Purified anti-RCAN1 Antibody, 100μg","description":"\u003cp\u003eRCAN1 is a protein that inhibits the calcineurin\/NFAT signaling pathway via it’s interaction with calcineruin A. RCAN1 has three different transcript variants, among which RCAN1.4 has been shown to regulate gene expression, cell migration and tubular morphogenesis in endothelial cells. Dysfunction of RCAN1 has been reported to impact the development of central nervous system, and is clinically linked to Down syndrome. It has also been reported that chronic overexpression of RCAN1 leads to formation of neurofibrillary tangles (NFT), and thus may play a role in neurodegenerative diseases such as AD.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human RCAN1\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2814606 (BioLegend Cat. No. 866201) AB_2814607 (BioLegend Cat. No. 866202)\u003cbr\u003e\nStructure: RCAN1 is a 252 amino acid protein with predicted molecular mass of ~ 28 kD, and observed molecular masses of ~ 35 kD (RCAN1L) and ~24 kD (RCAN1S) by WB.\u003cbr\u003e\nDistribution: Tissue Distribution: Ubiquitously expressed Cellular Distribution: Nucleus and Cytosol\u003cbr\u003e\nFunction: RCAN1 inhibits the calcineurin\/NFAT signaling pathway\u003cbr\u003e\nInteraction: RAF1, PPP3CA, PPP3R1, Calcineurin A\u003cbr\u003e\nCell Type: Microglia\u003cbr\u003e\nBiology Area: Cell Biology, Neurodegeneration, Neuroscience, Signal Transduction, Synaptic Biology\u003cbr\u003e\nAntigen References: Porta S, et al. 2007. Hum Mol Genet. 16(9):1039 Torac E, et al. 2014. J Med Life. 7(4):481 Wu Y, et al. 2014, Mol Neurobiol. 50(3):1085 Harris CD, et al. 2005. Cell Mol Life Sci. 62(21):2477\u003cbr\u003e\nGene ID: 182754720266766\u003cbr\u003e\nUniProt: View information about RCAN1 on UniProt.org\u003cbr\u003e\nClone: A18067A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Regulator of Calcineurin 1, DSCR1\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866060443817,"sku":"866202","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-866202","provider":"Iright","version":"1.0","type":"link"}