{"product_id":"biolegend-867201","title":"Biolegend, 867201, Purified anti-CKMT1 Antibody, 25μg","description":"\u003cp\u003eCKMT1 is the mitochondrial specific creatine kinase subunit that is ubiquitously expressed in mammals. CKMT1 is mainly localized to the mitochondrial intermembrane space and plays an important role in cellular energetics. Impairment in CKMT1 due to oxidative and radical-induced damage has been reported in numerous diseases including neurodegenerative disorders. Overexpression of CKMT1 is observed in several tumors in which high energy consumption is required for proliferation.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Purified recombinant human CKMT1 fragment expressed in E. coli.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedIHC-P, ICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 10 µg per mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 2.0 - 10 µg\/mL is suggested. For immunocytochemistry, a concentration range of 2.0 - 10 μg\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Fihurka O, et al. 2023. Biomolecules. 13:. PubMed Fihurka O, et al. 2022. Int J Mol Sci. 23:. PubMed\u003cbr\u003e\nRRID: AB_2810799 (BioLegend Cat. No. 867201) AB_2810800 (BioLegend Cat. No. 867202)\u003cbr\u003e\nStructure: CKMT1 is a 417 amino acid protein with predicted and observed molecular mass of ~47 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Mainly expressed in brain, appendix, tonsil, skin, and colon Cellular Distribution: Mitochondrion and cytosol\u003cbr\u003e\nFunction: CKMT1 plays a central role in energy transduction in tissues with large, fluctuating energy demands such as the brain.\u003cbr\u003e\nInteraction: CKMT1 exists as an octamer composed of four homodimers\u003cbr\u003e\nCell Type: Neurons\u003cbr\u003e\nBiology Area: Cancer Biomarkers, Cell Death, Neurodegeneration, Neuroinflammation, Neuroscience\u003cbr\u003e\nMolecular Family: Mitochondrial Markers\u003cbr\u003e\nAntigen References: Gramage E, et al. 2013. Toxicology. 10.1016\/j.tox.2013.02.013. Tanimura A, et al. 2014. PLoS One. 9(2):e89916. Onda T, et al. 2006. Br J Cancer. 94:698-709.\u003cbr\u003e\nGene ID: 11591271629593\u003cbr\u003e\nUniProt: View information about CKMT1 on UniProt.org\u003cbr\u003e\nClone: 1A6-C7-G10\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CKMT1A, CKMT1B, Creatine Kinase, Mitochondrial 1A\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860834898089,"sku":"867201","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-867201","provider":"Iright","version":"1.0","type":"link"}