{"product_id":"biolegend-867402","title":"Biolegend, 867402, Purified anti-SLC6A1 Antibody, 100μg","description":"\u003cp\u003eSLC6A1 is the gene that encodes GABA transporter 1 (GAT1) and functions as the major presynaptic protein in neurons involved in the removal of excessive GABA from the synaptic cleft and the extrasynaptic space. Diseases associated with GAT1 include neurodevelopmental disorders such as schizophrenia and seizure.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: KLH-conjugated C-terminal peptide of mouse SLC6A1.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2.0 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Avoid boiling lysates before loading to SDS for WB.\u003cbr\u003e\nRRID: AB_2810801 (BioLegend Cat. No. 867401) AB_2810802 (BioLegend Cat. No. 867402)\u003cbr\u003e\nStructure: GAT1 is a 599 amino acid protein with predicted and observed molecular mass of ~ 67 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Brain Cellular Distribution: Plasma membrane\u003cbr\u003e\nFunction: GAT1 is a GABA transporter protein that removes excessive GABA from the synaptic cleft and the extrasynaptic space.\u003cbr\u003e\nInteraction: MPP5, STX1A\u003cbr\u003e\nLigand\/Receptor: GABA\u003cbr\u003e\nCell Type: Astrocytes, GABAergic Neurons, Mature Neurons, Neurons, Oligodendrocytes\u003cbr\u003e\nBiology Area: Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Synaptic Biology\u003cbr\u003e\nMolecular Family: Neurotransmitter Receptor Trafficking\/Endocytosis, Presynaptic proteins, Synaptic Vesicle Trafficking\/Endocytosis\u003cbr\u003e\nAntigen References: Zafar S, et al. 2018. Front Chem. 6:397. Lie MEK, et al. 2017. Adv. Neurobiol. 16:137-167. Zhou Y, Danbolt NC. 2013. Front Endocrinol (Lausanne). 4:165.\u003cbr\u003e\nGene ID: 652923233379212\u003cbr\u003e\nUniProt: View information about SLC6A1 on UniProt.org\u003cbr\u003e\nClone: A18095C\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: GAT-1, GABA Transporter\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866061787305,"sku":"867402","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-867402","provider":"Iright","version":"1.0","type":"link"}