{"product_id":"biolegend-867602","title":"Biolegend, 867602, Purified anti-Dynactin 1 (N-Terminus) Antibody, 100μg","description":"\u003cp\u003eDynactin 1 is the largest subunit of the macromolecular complex dynactin, which is essential for dynein-mediated retrograde transport of vesicles and organelles. Dynactin 1 is clinically identified as a causative gene for Perry syndrome (PS), which is a neurodegenerative disease characterized by autosomal dominant inheritance, parkinsonism, and central hypoventilation. Mutations in dynactin 1 are also associated with neurodegenerative diseases, such as amyotrophic lateral sclerosis and frontotemporal dementia.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Purified recombinant Dynactin 1 protein fragments expressed in E.coli.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2814614 (BioLegend Cat. No. 867601) AB_2814615 (BioLegend Cat. No. 867602)\u003cbr\u003e\nStructure: Dynactin 1 is a 1278 amino acid protein with two reported isoforms. A brain-specific isoform with predicted and observed molecular mass of ~135 kD, and a ubiquitously expressed isoform with predicted and observed molecular mass of ~150 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Ubiquitously expressed Cellular Distribution: Cytoskeleton, cytosol, and nucleus\u003cbr\u003e\nFunction: Dynactin 1 recruits dynein to microtubules and facilitates retrograde transport of vesicles and organelles.\u003cbr\u003e\nInteraction: Dynactin 1 forms homodimer and interacts with dynein.\u003cbr\u003e\nBiology Area: Cell Motility\/Cytoskeleton\/Structure, Neurodegeneration, Neuroscience, Protein Trafficking and Clearance, Synaptic Biology\u003cbr\u003e\nMolecular Family: Adaptor Proteins, Carrier Proteins, Cytoskeletal Proteins, Neurotransmitter Receptor Trafficking\/Endocytosis, Presynaptic proteins, Synaptic Vesicle Trafficking\/Endocytosis\u003cbr\u003e\nAntigen References: Konno T, et al. 2017. Parkinsonism Relat Disord. 41:14. Houlden H, et al. 2012. Acta Neuropath. 124(3):325. Tanaka F, et al. 2011. Rinsho Shinkeigaku. 51(11):1189.\u003cbr\u003e\nGene ID: 1639\u003cbr\u003e\nUniProt: View information about Dynactin 1 on UniProt.org\u003cbr\u003e\nClone: 3D5-C6-D5\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: DCTN1, Dynactin Subunit 1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862393180329,"sku":"867602","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-867602","provider":"Iright","version":"1.0","type":"link"}