{"product_id":"biolegend-868002","title":"Biolegend, 868002, Purified anti-Ataxin-2 Antibody, 100μg","description":"\u003cp\u003eAtaxin-2 is a polyglutamine protein involved in several biological processes including regulation of mRNA translation. Ataxin-2 contains 2 domains, Sm1 and Sm2, that are implicated in RNA splicing and protein interactions. In the brain, ataxin-2 is expressed in the hypothalamus, the brain region that is responsible for controlling energy balance and metabolism homeostasis. Mutations in ataxin-2 are associated with the development of spinocerebellar ataxia type 2.  Ataxin-2 mutant protein with intermediate-length polyglutamine expansion (27-33 polyQ) modifies TDP-43 toxicity and is associated with an increased risk of developing amyotrophic lateral sclerosis.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human ataxin-2 recombinant protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedIHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1 - 10 µg per ml. For formalin-fixed paraffin-embedded immunohistochemical staining, a concentration range of 1 - 10 µg\/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2810809 (BioLegend Cat. No. 868001) AB_2810810 (BioLegend Cat. No. 868002)\u003cbr\u003e\nStructure: Human ataxin-2 is a 1,313 amino acid protein with a predicted molecular mass of 140 kD.\u003cbr\u003e\nDistribution: Tissue distribution: Brain, spinal cord, heart, liver, skeletal muscle, pancreas, and placenta Cellular distribution: Cytoplasm\u003cbr\u003e\nFunction: Ataxin-2 is involved in the RNA splicing, protein interactions, and metabolic homeostasis.\u003cbr\u003e\nInteraction: Ataxin-2 interacts with TARDBP, RBFOX1, polyribosomes, SH3GL2, SH3GL3, SH3KBP1, CBL, EGFR, and ATXN2L.\u003cbr\u003e\nCell Type: Neurons\u003cbr\u003e\nBiology Area: Neurodegeneration, Neuroscience, Synaptic Biology\u003cbr\u003e\nAntigen References: Carmo-Silva S, et al. 2017. Trends Endocrinol Metab. 28(4):309-318. van den Heuvel DM, et al. 2014. Trends Mol Med. 20(1):25-35. Becker LA, et al. 2017. Nature. 544(7650):367-371. Scoles DR, et al. 2017. Nature. 544(7650):362-366\u003cbr\u003e\nGene ID: 6311\u003cbr\u003e\nUniProt: View information about Ataxin-2 on UniProt.org\u003cbr\u003e\nClone: A17203C\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Spinocerebellar ataxia type 2 protein, Trinucleotide repeat-containing gene 13 protein, ATX2, SCA2, TNRC13, SCA2\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866057560233,"sku":"868002","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-868002","provider":"Iright","version":"1.0","type":"link"}