{"product_id":"biolegend-868301","title":"Biolegend, 868301, Purified anti-Fascin-1 Antibody, 25μg","description":"\u003cp\u003eFascin is a 55 kD F-actin binding protein that is involved in cell motility and migration. Fascin plays an important role in the organization and formation of membrane ruffles, stress fibers, and a diverse set of cell protrusions, such as filopodia. In the mouse subventricular zone-derived migratory neuroblasts, Fascin is highly upregulated to guide the migration of cells along the rostral migratory stream. In Drosophila , Fascin controls neuronal class-specific dendrite arbor morphology to elicit the accurate establishment of neuronal circuits.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human Fascin full-length protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2820172 (BioLegend Cat. No. 868301) AB_2820173 (BioLegend Cat. No. 868302)\u003cbr\u003e\nStructure: Human Fascin is a 493 amino acid protein with a molecular mass of 54 kD.\u003cbr\u003e\nDistribution: Tissue distribution: Ubiquitously expressed Cellular distribution: Cytosol, cytoskeleton, and stress fibers\u003cbr\u003e\nFunction: Fascin is involved in the assembly of filamentous actin.\u003cbr\u003e\nInteraction: Fascin interacts with RUFY3, beta-catenin, and PLXNB3.\u003cbr\u003e\nCell Type: Neurons\u003cbr\u003e\nBiology Area: Cell Biology, Cell Motility\/Cytoskeleton\/Structure, Neurodegeneration, Neuroscience\u003cbr\u003e\nMolecular Family: Cytoskeletal Proteins\u003cbr\u003e\nAntigen References: Yamashiro S, et al. 1998. Mol Biol Cell. 9(5): 993-1006. Nagel J, et al. 2012. Development 139, 2999-3009 Sonego M, et al. 2013. J Neurosci. 33(30): 12171–85.\u003cbr\u003e\nGene ID: 6624\u003cbr\u003e\nUniProt: View information about Fascin-1 on UniProt.org\u003cbr\u003e\nClone: CPTC-Fascin1-2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: FASN1, 55 kDa actin-bundling protein, Singed-like protein, p55\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862994309289,"sku":"868301","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-868301","provider":"Iright","version":"1.0","type":"link"}