{"product_id":"biolegend-869602","title":"Biolegend, 869602, Purified anti-Gemin 4 Antibody, 100μg","description":"\u003cp\u003eGemin 4 is one of the core components of the survival of motor neurons (SMNs) macromolecule protein complex, which plays an important role in the assembly and re-structuring of small nucleoproteins and transcriptosomes. Recent studies have shown that one of the three putative nuclear localization signal motifs in Gemin 4 is necessary and sufficient to direct the nuclear import of the other two SMN complex components, Gemin 2 and Gemin 3. This suggests that Gemin 4 plays an essential role in mammalian snRNP biogenesis via facilitating the import of the SMN complex or subunits into the nucleus.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Histidine-tagged recombinant protein corresponding to human Gemin 4\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Battle DJ, et al. 2007. J. Biol Chem. 282(38):27953 (WB)\u003cbr\u003e\nRRID: AB_2814637 (BioLegend Cat. No. 869601) AB_2814638 (BioLegend Cat. No. 869602)\u003cbr\u003e\nStructure: Gemin 4 is a 1058 amino acid protein with predicted and observed molecular mass of ~120 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Ubiquitously expressed Cellular Distribution: Nucleus and cytosol\u003cbr\u003e\nFunction: Gemin 4 is a component of the SMN macromolecule protein complex.\u003cbr\u003e\nInteraction: Gemin 4 is a part of the core SMN complex that contains SMN 1-8.\u003cbr\u003e\nBiology Area: Neuroscience, Synaptic Biology, Transcription Factors\u003cbr\u003e\nMolecular Family: Nuclear Markers\u003cbr\u003e\nAntigen References: Meier ID, et al. 2018. Biol Open. 7(2) Battle DJ, et al. 2007. J Biol Chem. 282(38):27953 Wang JL, et al. 2004. Biochim Biophys Acta. 1673(1-2):75.\u003cbr\u003e\nGene ID: 50628\u003cbr\u003e\nUniProt: View information about Gemin 4 on UniProt.org\u003cbr\u003e\nClone: 17D10\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: P97, Gem Nuclear Organelle Associated Protein 4, Component of Gems 4, Gem-Associated Protein 4, HCC-Associated Protein 1, Gemin-4, Gem (Nuclear Organelle) Associated Protein 4\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860827361449,"sku":"869602","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-869602","provider":"Iright","version":"1.0","type":"link"}