{"product_id":"biolegend-870602","title":"Biolegend, 870602, Purified anti-FAF1 Antibody, 100μg","description":"\u003cp\u003eFAS-associated factor 1 (FAF1) is an evolutionarily conserved protein with multiple protein interaction domains, including a FAS-interacting domain (FID), a death effector domain interacting domain (DEDID), and multi-ubiquitin-related domains. Initially identified as a member of FAS death-inducing signaling complex, FAF1 plays diverse roles in apoptotic and survival pathways. It may also serve as a scaffolding protein that regulates protein degradation in the ubiquitin-proteasome pathway. FAF1 is abundantly expressed in the brain where it modulates cell death. FAF1 also serves as a substrate for parkin, a key protein implicated in the pathogenesis of Parkinson’s disease (PD). Wild type parkin ubiquitinates FAF1 and promotes its degradation, while PD-linked mutant parkin causes abnormal accumulation of FAF1.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant full length protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.5 - 10 µg\/mL. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2820196 (BioLegend Cat. No. 870601) AB_2820197 (BioLegend Cat. No. 870602)\u003cbr\u003e\nStructure: Human FAF1 is a 650 amino acid protein with a predicted molecular mass of 74 kD.\u003cbr\u003e\nDistribution: Tissue distribution: Ubiquitously expressed Cellular distribution: Plasma membrane, nucleus, cytosol, endoplasmic reticulum\u003cbr\u003e\nFunction: FAF1 is an ubiquitin-binding protein, required for the progression of DNA replication forks.\u003cbr\u003e\nInteraction: Interacts with CDT1, ATPase VCP\/p97, FAS, and NLRP12.\u003cbr\u003e\nCell Type: Neurons\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Cycle\/DNA Replication, Cell Death, Neuroscience, Ubiquitin\/Protein Degradation\u003cbr\u003e\nAntigen References: Menges CW, et al. 2009. Cell Cycle. 8(16):2528-34. Sul JW, et al. 2013. Hum Mol Genet. 22(8):1558-73. Cheng K, et al. 2011. J Neurosci. 31(33):11905-13.\u003cbr\u003e\nGene ID: 11124\u003cbr\u003e\nUniProt: View information about FAF1 on UniProt.org\u003cbr\u003e\nClone: CPTC-FAF1-1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: FAS-associated factor 1, hFAF1, UBX domain-containing protein 12, UBX domain-containing protein 3A, UBXD12, UBXN3A, Fas (TNFRSF6) Associated Factor 1, TNFRSF6-Associated Factor 1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862994210985,"sku":"870602","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-870602","provider":"Iright","version":"1.0","type":"link"}