{"product_id":"biolegend-870702","title":"Biolegend, 870702, Purified anti-UBE2V1 Antibody, 100μg","description":"\u003cp\u003eUbiquitination is a common post-translational modification of proteins and plays an important role in protein homeostasis. UBE2V1 encodes one of the ubiquitin-conjugating E2 enzyme variant proteins (UBE2V), which lacks the conserved cysteine residue required for the catalytic activity of E2s. Elevated expression of UBE2V1 has been associated with tumor development; however, it is not clear whether it functions as an oncogene or tumor suppressor gene. In addition, UBE2V1 is a key component in TRAF6 to control NF-κB activation.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat, Drosophila\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human UBE2V1 protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 1.0 - 10 µg\/mL. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2832874 (BioLegend Cat. No. 870701) AB_2832875 (BioLegend Cat. No. 870702)\u003cbr\u003e\nStructure: Human UBE2V1 is a 147 amino acid protein with a predicted molecular mass of 16 kD.\u003cbr\u003e\nDistribution: Tissue distribution: Ubiquitously expressed Cellular distribution: Cytosol, nucleus\u003cbr\u003e\nFunction: UBE2V1 is a ubiquitin-conjugating enzyme.\u003cbr\u003e\nCell Type: Astrocytes, Neurons\u003cbr\u003e\nBiology Area: Cell Biology, Cell Cycle\/DNA Replication, Neuroinflammation, Neuroscience, Protein Trafficking and Clearance, Ubiquitin\/Protein Degradation\u003cbr\u003e\nMolecular Family: Enzymes and Regulators, Ligases\u003cbr\u003e\nAntigen References: Ma L, et al. 1998. Oncogene. 17:1321-6. Shen T, et al. 2018. J. Hematol. Oncol. 11:95. Wu X, Karin M. 2015. Immunol. Rev. 266:161-74.\u003cbr\u003e\nGene ID: 7335\u003cbr\u003e\nUniProt: View information about UBE2V1 on UniProt.org\u003cbr\u003e\nClone: A18196A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Ubiquitin-conjugating enzyme E2 variant 1, UEV-1, CROC-1, TRAF6-regulated IKK activator 1 beta Uev1A\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866063622313,"sku":"870702","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-870702","provider":"Iright","version":"1.0","type":"link"}