{"product_id":"biolegend-870901","title":"Biolegend, 870901, Purified anti-VCP Antibody, 25μg","description":"\u003cp\u003eValocin-containing protein (VCP) is a member of a family of proteins that include putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP associates with clathrin and heat-shock protein Hsc70 to form a complex that functions as a chaperon to unfold and transport proteins to different cellular compartments. Diseases associated with VCP include inclusion body myopathy with early-onset Paget's disease, and frontotemporal dementia 1 and amyotrophic lateral sclerosis 14, with or without frontotemporal dementia.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant Human VCP Protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedIHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.5 - 2.0 µg\/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 0.5 - 10 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2861105 (BioLegend Cat. No. 870901) AB_2861106 (BioLegend Cat. No. 870902)\u003cbr\u003e\nStructure: VCP is an 806 amino acid protein with predicted molecular mass of ~89 kD and observed molecular mass at ~ 97 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Ubiquitously expressed Cellular Distribution: Cytosol, endoplasmic reticulum, nucleus, extracellular, and lysosome\u003cbr\u003e\nFunction: Protein Trafficking, protein clearance\u003cbr\u003e\nInteraction: Forms homohexamers and a ternary complex with STX5A and NSFLC. Interacts with NPLOC4, UFD1, and clathrin.\u003cbr\u003e\nCell Type: Astrocytes, Dopaminergic Neurons, Endothelial cells, Epithelial cells, GABAergic Neurons, Glutamatergic Neurons, Mature Neurons, Microglia, Neural Stem Cells, Neurons, Oligodendrocytes\u003cbr\u003e\nBiology Area: Cell Motility\/Cytoskeleton\/Structure, Neurodegeneration, Neuroinflammation, Neuroscience, Protein Misfolding and Aggregation, Protein Trafficking and Clearance, Signal Transduction, Ubiquitin\/Protein Degradation\u003cbr\u003e\nMolecular Family: Endoplasmic Reticulum Markers, Neurotransmitter Receptor Trafficking\/Endocytosis, Synaptic Vesicle Trafficking\/Endocytosis\u003cbr\u003e\nAntigen References: Lan B, et al. 2017. Curr Mol Med. 17(9):608. van den Boom J \u0026amp; Meyer H. 2018. Mol Cell. 69(2):182. Van Mossevelde S, et al. 2018. Nat Rev Neurol. 14(6):363.\u003cbr\u003e\nGene ID: 7415269523116643\u003cbr\u003e\nUniProt: View information about VCP on UniProt.org\u003cbr\u003e\nClone: A18143C\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Valosin-Containing Protein, CDC48\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866062672041,"sku":"870901","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-870901","provider":"Iright","version":"1.0","type":"link"}