{"product_id":"biolegend-871102","title":"Biolegend, 871102, Purified anti-EIF2AK2 Antibody, 100μg","description":"\u003cp\u003eIFN-induced dsRNA-dependent serine\/threonine-protein kinase (EIF2AK2) is an important component of the innate immune response to viral infection. The N-terminal of EIF2AK2 contains a double stranded RNA (dsRNA) binding domain, which binds dsRNA introduced to the host cells by viral infection, and activates a pro-apoptotic signal in the host cell. Recent studies have shown that activation of EIF2AK2 can lead to the accumulation of amyloid beta in Alzheimer disease patients, suggesting it plays a role in neurodegenerative disorders.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Purified recombinant human EIF2AK2\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody was purified by affinity chromatography.\u003cbr\u003e\nApplication: WB - Quality testedICC, IHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.5 - 1.0 µg\/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 0.5 - 10 µg\/mL is suggested. For immunocytochemistry, a concentration range of 0.5 - 10 μg\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This antibody reacts stronger with rat tissue samples than human cell line samples. Recommended WB usage for rat brain: 0.5 - 2 µg\/mL; Recommended WB usage for human cell lines: 2 - 10 µg\/mL\u003cbr\u003e\nRRID: AB_2832878 (BioLegend Cat. No. 871101) AB_2832879 (BioLegend Cat. No. 871102)\u003cbr\u003e\nStructure: Human EIF2AK2 has 2 isoforms. Isoform 1 is an 551 amino acid protein with predicted and observed molecular mass of ~62 kD; Isoform 2 is an 510 amino acid protein with predicted and observed molecular mass of ~57 kD\u003cbr\u003e\nDistribution: Tissue Distribution: Ubiquitously expressed Cellular Distribution: Nucleus, Cytosol\u003cbr\u003e\nFunction: Innate immune response against viral infection, central to stress signals\u003cbr\u003e\nInteraction: Forms homodimer, interacts with DNAJC3, STRBP, ADAR\u003cbr\u003e\nLigand\/Receptor: dsRNA\u003cbr\u003e\nCell Type: Astrocytes, Endothelial cells\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Cell Death, Neurodegeneration, Neuroinflammation, Neuroscience, Signal Transduction\u003cbr\u003e\nMolecular Family: APP\/β-Amyloid, Innate Immune Signaling, Protein Kinases\/Phosphatase\u003cbr\u003e\nAntigen References: Chesnokova E, et al. 2017. Int J Mol Sci. 18(10). Bou-Nader C, et al. 2019. RNA. 25(5):539. Dzananovic E, et al. 2018. Biotechnol Genet Eng Rev. 34(1):33.\u003cbr\u003e\nGene ID: 561054287\u003cbr\u003e\nUniProt: View information about EIF2AK2 on UniProt.org\u003cbr\u003e\nClone: A17195G\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: PKR, PRKR, E2AK2\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866056347817,"sku":"871102","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-871102","provider":"Iright","version":"1.0","type":"link"}