{"product_id":"biolegend-871901","title":"Biolegend, 871901, Purified anti-Desmoglein 3 Antibody, 25μg","description":"\u003cp\u003eDesmoglein-3 is a glycoprotein mainly expressed in the basal lower layers of the epidermis and on mucosal surfaces. It is the Ca 2+ binding transmembrane components of the desmosomes that functions as cell-cell junctions between epithelial cells as well as other cell types. Clinically, desmoglein-3 has been identified as one of the autoantigens in the autoimmune skin blistering disease pemphigus vulgaris. It also serves as a prognostic marker of esophageal squamous cell carcinoma.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.5 - 1.0 µg\/mL. For immunocytochemistry, a concentration range of 2.0 - 10 μg\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Wan H, et al. 2016. Data Brief. 6:124-34 (WB, ICC) Walter E, et al. 2017. Sci Rep. 7:3579 (ICC) Tsang SM, et al. 2010. PloS One. 5:e14211 (WB, ICC)\u003cbr\u003e\nRRID: AB_2876750 (BioLegend Cat. No. 871901) AB_2876750 (BioLegend Cat. No. 871902)\u003cbr\u003e\nStructure: Desmoglein 3 is a 999 amino acid protein with predicted molecular mass of 108 kD and observed molecular mass of ~130 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Esophagus, skin, tonsil Cellular Distribution: Plasma membrane, cytosol, extracellular\u003cbr\u003e\nFunction: Desmoglein-3 is the Ca2+ binding transmembrane components of the desmosomes that functions as cell-cell junctions between epithelial cells as well as other cell types.\u003cbr\u003e\nInteraction: PKP3, JUP, WWOX, FRMD1, OAZ3\u003cbr\u003e\nCell Type: Endothelial cells, Epithelial cells\u003cbr\u003e\nBiology Area: Adaptive Immunity, Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Signal Transduction\u003cbr\u003e\nMolecular Family: Adhesion Molecules, Gap Junction Proteins\u003cbr\u003e\nAntigen References: Mahmoudi H, et al. 2020. Int J Immunogenet. 47:41-9 Spindler V \u0026amp; Waschke J. 2018. Front immunol. 9:136 Pan M, et al. 2015. J Dermatol. 42:11-7\u003cbr\u003e\nGene ID: 1830\u003cbr\u003e\nUniProt: View information about Desmoglein 3 on UniProt.org\u003cbr\u003e\nClone: DSG3\/5H10\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: DSG3, PVA\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46863020163241,"sku":"871901","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-871901","provider":"Iright","version":"1.0","type":"link"}