{"product_id":"biolegend-937702","title":"Biolegend, 937702, Purified anti-Filamin A Antibody, 100μg","description":"\u003cp\u003eFilamin A is an actin binding protein which crosslinks actin filaments into an orthogonal network and helps anchor membrane glycoproteins to cytoskeleton. Filamin A is also important in modifying cell shape in cell migration by changing the cytoskeleton. Filamin A is involved in ciliogenesis, cell adhesion and in the development of blood vessels, and other organs. Diseases associated with Filamin A include Melnick-Needles syndrome, otopalatodigital syndrome, periventricular nodular heterotopias and frontometaphyseal dysplasia.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Partial recombinant human Filamin A\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested KO\/KD-WB, ICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.0625 - 1.0 µg\/mL. For immunocytochemistry, a concentration range of 2.0 - 5.0 μg\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone recognizes human and mouse Filamin A. Clone works well in ICC when cells are permeabilized with either Triton X-100 or methanol. Clone is not recommended for IP.\u003cbr\u003e\nRRID: AB_2876755 (BioLegend Cat. No. 937701) AB_2876755 (BioLegend Cat. No. 937702)\u003cbr\u003e\nStructure: Filamin A is a 2647 amino acid protein with a predicted molecular weight of 281 kD.\u003cbr\u003e\nDistribution: Filamin A is primarily localized in the actin filaments, plasma membrane and cytosol.\u003cbr\u003e\nFunction: Actin binding protein\u003cbr\u003e\nInteraction: Actin, FLNB\u003cbr\u003e\nMolecular Family: Cytoskeletal Proteins\u003cbr\u003e\nAntigen References: Feng Y, et al. 2006. Proc Natl Acad Sci U S A. 103:19836-41. Patel-Hett S, et al. 2011. Blood. 118:1641-52. Sun Y, et al. 2010. Am J Hum Genet. 87:146-53. Foley C, et al. 2010. Mol Syndromol. 1:121-126.\u003cbr\u003e\nGene ID: 2316\u003cbr\u003e\nUniProt: View information about Filamin A on UniProt.org\u003cbr\u003e\nClone: W18172E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Filamin A, Endothelial Actin-Binding Protein, Actin Binding Protein 280, Non-Muscle Filamin, Filamin A Alpha, Alpha-Filamin, Filamin-1, Filamin-A, ABP-280, FLN-A, FLN1, FLN, Filamin A Alpha (Actin Binding Protein 280),\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866334646441,"sku":"937702","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-937702","provider":"Iright","version":"1.0","type":"link"}