{"product_id":"biolegend-944401","title":"Biolegend, 944401, Purified anti-SARS-CoV-2 S Protein S1 Antibody, 25μg","description":"\u003cp\u003eSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a single- stranded RNA virus that belongs in a family of viruses known as coronaviruses. SARS-CoV-2 infection, known as COVID-19, was declared a pandemic by WHO on March 11, 2020 and among other symptoms leads to respiratory infection, pulmonary failure which can be fatal. SARS-CoV-2 is structurally composed of 4 main proteins (e.g. spike glycoprotein, envelope glycoprotein, membrane glycoprotein and nucleocapsid protein) and several accessory proteins. The spike glycoprotein (S) is a transmembrane molecule that forms homotrimers on the surface of the virus and facilitates virulence through binding to angiotensin-converting enzyme 2 (ACE2) expressed on host cells. This protein is composed of two subunits S1 and S2. S1 subunit is responsible for binding to the host cell via ACE-2 receptor and S2 for fusion with the host cell.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: SARS-CoV-2\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Partial recombinant protein corresponding to the S1 subunit of SARS-CoV-2 S protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested ELISA - Verfied\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg\/mL. For ELISA applications, a concentration of 65.4 ng\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: BioLegend offers multiple clones that recognize SARS-CoV-2 S protein S1. Clone A20103H displayed the strongest performance for western blot of all clones validated for the application.\u003cbr\u003e\nRRID: AB_2890872 (BioLegend Cat. No. 944401) AB_2890872 (BioLegend Cat. No. 944402)\u003cbr\u003e\nStructure: Spike glycoprotein is a homotrimer. Each monomer consists of 1,273 a.a with a molecular weight of approximately 141 kD and consists of S1 and S2 subunits. S1 subunit is 673 a.a. long.\u003cbr\u003e\nDistribution: Viral envelope protein, host cell membrane, host cell endoplasmic reticulum-Golgi intermediate compartment membrane\u003cbr\u003e\nFunction: Host cell surface receptor binding\u003cbr\u003e\nInteraction: ACE2\u003cbr\u003e\nLigand\/Receptor: ACE2\u003cbr\u003e\nBiology Area: COVID-19\u003cbr\u003e\nAntigen References: Walls AC, et al. 2020. Cell. 181:281-292. Yan R, et al. 2020. Science. 367:1444-1448. Wrapp D, et al. 2020. Science. 367:1260-1263. Shang J, et al. 2020. Proc Natl Acad Sci U S A. 117:11727-11734.\u003cbr\u003e\nGene ID: 43740568\u003cbr\u003e\nUniProt: View information about Viral Protein on UniProt.org\u003cbr\u003e\nClone: A20103H\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Spike glycoprotein, Sglycoprotein (E2)\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866071027881,"sku":"944401","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-944401","provider":"Iright","version":"1.0","type":"link"}