{"product_id":"biolegend-949401","title":"Biolegend, 949401, Purified anti-TACC3 Antibody, 25μg","description":"\u003cp\u003eTACC3, also referred to as transforming acidic coiled-coil containing protein 3 or ERIC1, is involved in the process of mitotic spindle assembly and stabilization. TACC3 forms a complex with ch-TOG\/clathrin to stabilize the kinetochore fibers of the mitotic spindle. It acts as an inter-microtubule bridge and maintains kinetochore tension. TACC3 is frequently overexpressed in many cancers and may serve as a therapeutic and prognostic marker in breast cancer. Multiple solid tumors have been described where TACC3 is found as a fusion with various FGFR family members, which results in constitutive receptor tyrosine kinase activity of the FGFR partner.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Partial recombinant human TACC3 protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested ICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg\/mL. For immunocytochemistry, a concentration range of 1.25 - 5.0 μg\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This clone was tested for ICC using HeLa cells fixed with methanol or 4% paraformaldehyde and permeabilized with either methanol or Triton X-100. All three methods were compatible with TACC3 staining.\u003cbr\u003e\nRRID: AB_2910516 (BioLegend Cat. No. 949401) AB_2910516 (BioLegend Cat. No. 949402)\u003cbr\u003e\nStructure: TACC3 is an 838 amino acid protein with a predicted molecular weight of 90 kD.\u003cbr\u003e\nDistribution: Ubiquitously expressed\/cytoplasm and mitotic spindle assembly\u003cbr\u003e\nFunction: Cell cycle, cell division, mitosis, differentiation\u003cbr\u003e\nBiology Area: Cell Biology\u003cbr\u003e\nMolecular Family: Microtubules\u003cbr\u003e\nAntigen References: Gangisetty, et al. 2004. Oncogene. 23:2559. Costa R, et al. 2016. Oncotarget. 7:55924. Ding, et al. 2017. Cytoskeleton. 74:369. Huo Q, et al. 2021. Front. Genet. 12:640078.\u003cbr\u003e\nGene ID: 10460\u003cbr\u003e\nUniProt: View information about TACC3 on UniProt.org\u003cbr\u003e\nClone: W18281B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Transforming acidic coiled-coil containing protein 3 , ERIC1\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866338676905,"sku":"949401","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-949401","provider":"Iright","version":"1.0","type":"link"}