{"product_id":"cst-12735t","title":"CST,  12735T, NXF1 (D5X4G) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying NXF1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, NXF1 (D5X4G) Rabbit Monoclonal Antibody (CST #12735) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nNXF1 (D5X4G) Rabbit Monoclonal Antibody recognizes endogenous levels of total NXF1 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln211 of human NXF1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nmRNA export is a process that is tightly coupled to mRNA splicing (1-4). Splicing and packaging of mRNAs in the form of an mRNA-protein complex (mRNP) leads to the recruitment of the mRNA export adaptor THOC4\/ALY, via its interaction with the splicing factor UAP56, forming a large complex termed the transcription-export complex (TREX) (1,2,5). THOC4\/ALY then directly interacts with NXF1\/TAP, a part of the heterodimer that targets the mRNP to the nuclear pore complex, resulting in the shuttling of mRNP out of the nucleus and into the cytoplasm (1-3,6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDKFZp667O0311; MEX67; mRNA export factor TAP; Nuclear RNA export factor 1; NXF1; TAP; tip associating protein; Tip-associated protein; Tip-associating protein\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 70\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797578436777,"sku":"12735T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/cst-12735t","provider":"Iright","version":"1.0","type":"link"}