{"product_id":"cst-34594t","title":"CST,  34594T, 4-1BB\/CD137\/TNFRSF9 (D2Z4Y) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying TNFRSF9. Validated for WB,IP,IHC,IF,F,F. Available in 2 sizes. Highly specific and rigorously validated in-house, 4-1BB\/CD137\/TNFRSF9 (D2Z4Y) Rabbit Monoclonal Antibody (CST #34594) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\nImmunohistochemistry (Paraffin): 1:50 - 1:200\nImmunofluorescence (Immunocytochemistry): 1:250 - 1:1000\nFlow Cytometry (Fixed\/Permeabilized): 1:400 - 1:1600\nFlow Cytometry (Live): 1:400 - 1:1600\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 58350 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunofluorescence (Immunocytochemistry), Flow Cytometry (Fixed\/Permeabilized), Flow Cytometry (Live)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\n4-1BB\/CD137\/TNFRSF9 (D2Z4Y) Rabbit Monoclonal Antibody recognizes endogenous levels of total 4-1BB\/CD137\/TNFRSF9 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a recombinant protein specific to the extracellular domain of human 4-1BB\/CD137\/TNFRSF9 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nTNFRSF9 is a member of the tumor necrosis factor receptor superfamily (1,2). It is also called 4-1BB or CD137 (1, 2). 4-1BB\/CD137\/TNFRSF9 is expressed in activated CD4+ and CD8+ T cells, natural killer cells and dendritic cells (2-5). The ligand 4-1BBL\/CD137L\/TNFSF9 on antigen presenting cells binds to 4-1BB\/CD137\/TNFRSF9 and costimulates the activation of T cells (5). The binding of agonistic antibodies to 4-1BB\/CD137\/TNFRSF9 also leads to costimulation for T cell activation (5). Studies have shown the effectiveness of targeting 4-1BB\/CD137\/TNFRSF9 by its agonistic antibodies in cancer immunotherapy (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n4-1BB; 4-1BB ligand receptor; CD137; CD137 antigen; CDw137; homolog of mouse 4-1BB; ILA; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; MGC2172; receptor protein 4-1BB; T cell antigen ILA; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNF receptor superfamily member 9; TNFRSF9; TNR9; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 32, 40\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799420588201,"sku":"34594T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/cst-34594t","provider":"Iright","version":"1.0","type":"link"}