{"product_id":"cst-34735s","title":"CST,  34735S, EXOSC10 (F4Q2B) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying EXOSC10. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, EXOSC10 (F4Q2B) Rabbit Monoclonal Antibody (CST #34735) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nEXOSC10 (F4Q2B) Rabbit Monoclonal Antibody recognizes endogenous levels of total EXOSC10 protein. This antibody detects a 32 kDa band of unknown origin.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly877 of human EXOSC10 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nExosome component 10 (EXOSC10), also known as RRP6 or autoantigen PM\/Scl-100, is a 3'-5' nuclear component of the exosome complex with 3'-5' exonuclease activity. EXOSC10 is essential for the 3' end formation of 5.8S rRNA, as well as the degradation of improperly spliced or polyadenylated mRNAs (1-3). Additionally, EXOSC10 regulates the proper 3' formation of small nucleolar RNAs (snoRNAs) (4). EXOSC10 is the antibody target in polymyositis-scleroderma overlap, an autoimmune disease (5-7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nautoantigen PM-SCL; Autoantigen PM\/Scl 2; EXOSC10; Exosome complex component 10; Exosome component 10; EXOSX; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; p2; p3; p4; PM-Scl; PM\/Scl-100; PMSCL; PMSCL2; Polymyositis\/scleroderma autoantigen 100 kDa; Polymyositis\/scleroderma autoantigen 2; polymyositis\/scleroderma autoantigen 2 (100kD); polymyositis\/scleroderma autoantigen 2, 100kDa; RRP6; Rrp6p\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 100\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799421866153,"sku":"34735S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/cst-34735s","provider":"Iright","version":"1.0","type":"link"}